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Fusion gene ID: 39691 |
FusionGeneSummary for TRPS1_PVT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRPS1_PVT1 | Fusion gene ID: 39691 | Hgene | Tgene | Gene symbol | TRPS1 | PVT1 | Gene ID | 7227 | 5820 |
| Gene name | transcriptional repressor GATA binding 1 | Pvt1 oncogene | |
| Synonyms | GC79|LGCR | LINC00079|MIR1204HG|MYC|NCRNA00079|onco-lncRNA-100 | |
| Cytomap | 8q23.3 | 8q24.21 | |
| Type of gene | protein-coding | ncRNA | |
| Description | zinc finger transcription factor Trps1tricho-rhino-phalangeal syndrome type I proteintrichorhinophalangeal syndrome Izinc finger protein GC79 | CXCR4/PVT1 fusionHIST1H2BD/PVT1 fusionMIR1204, MIR1205, MIR1206 and MIR1207 hostOncogene PVT-1 (MYC activator)PVT1/CASC8 fusionPVT1/CCDC26 fusionPVT1/IFRD1 fusionPVT1/IRF2BP2 fusionPVT1/LINC00824 fusionPVT1/MYC fusionPVT1/NFIL3 fusionPVT1/NSMCE | |
| Modification date | 20180519 | 20180520 | |
| UniProtAcc | Q9UHF7 | ||
| Ensembl transtripts involved in fusion gene | ENST00000395715, ENST00000220888, ENST00000519076, ENST00000520276, ENST00000519674, | ENST00000408388, | |
| Fusion gene scores | * DoF score | 14 X 6 X 3=252 | 15 X 10 X 9=1350 |
| # samples | 13 | 17 | |
| ** MAII score | log2(13/252*10)=-0.954912110471462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1350*10)=-2.98935275580049 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRPS1 [Title/Abstract] AND PVT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRPS1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12885770|21673316 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A0EX-01A | TRPS1 | chr8 | 116680772 | - | PVT1 | chr8 | 129108764 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000395715 | ENST00000408388 | TRPS1 | chr8 | 116680772 | - | PVT1 | chr8 | 129108764 | + |
| 5UTR-intron | ENST00000220888 | ENST00000408388 | TRPS1 | chr8 | 116680772 | - | PVT1 | chr8 | 129108764 | + |
| intron-intron | ENST00000519076 | ENST00000408388 | TRPS1 | chr8 | 116680772 | - | PVT1 | chr8 | 129108764 | + |
| intron-intron | ENST00000520276 | ENST00000408388 | TRPS1 | chr8 | 116680772 | - | PVT1 | chr8 | 129108764 | + |
| 5UTR-intron | ENST00000519674 | ENST00000408388 | TRPS1 | chr8 | 116680772 | - | PVT1 | chr8 | 129108764 | + |
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FusionProtFeatures for TRPS1_PVT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRPS1 | PVT1 |