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Fusion gene ID: 3957 |
FusionGeneSummary for BCAS3_ORMDL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BCAS3_ORMDL3 | Fusion gene ID: 3957 | Hgene | Tgene | Gene symbol | BCAS3 | ORMDL3 | Gene ID | 54828 | 94103 |
| Gene name | BCAS3, microtubule associated cell migration factor | ORMDL sphingolipid biosynthesis regulator 3 | |
| Synonyms | GAOB1|MAAB | - | |
| Cytomap | 17q23.2 | 17q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1 | ORM1-like protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H6U6 | Q8N138 | |
| Ensembl transtripts involved in fusion gene | ENST00000589222, ENST00000407086, ENST00000390652, ENST00000408905, ENST00000588462, ENST00000585744, ENST00000588874, ENST00000585812, | ENST00000304046, ENST00000579695, ENST00000394169, ENST00000584220, ENST00000582052, | |
| Fusion gene scores | * DoF score | 40 X 23 X 15=13800 | 6 X 2 X 5=60 |
| # samples | 47 | 6 | |
| ** MAII score | log2(47/13800*10)=-4.87586369998789 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
| Context | PubMed: BCAS3 [Title/Abstract] AND ORMDL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BCAS3 | GO:0043085 | positive regulation of catalytic activity | 17505058 |
| Hgene | BCAS3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17505058 |
| Hgene | BCAS3 | GO:0071391 | cellular response to estrogen stimulus | 17505058 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-KJ-A3U4-01A | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000589222 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000589222 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000589222 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000589222 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000589222 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000407086 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000407086 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000407086 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000407086 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000407086 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000390652 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000390652 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000390652 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000390652 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000390652 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000408905 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000408905 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000408905 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000408905 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000408905 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000588462 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000588462 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-5UTR | ENST00000588462 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000588462 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| 5CDS-intron | ENST00000588462 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000585744 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000585744 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000585744 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-intron | ENST00000585744 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-intron | ENST00000585744 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000588874 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000588874 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000588874 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-intron | ENST00000588874 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-intron | ENST00000588874 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000585812 | ENST00000304046 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000585812 | ENST00000579695 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-5UTR | ENST00000585812 | ENST00000394169 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-intron | ENST00000585812 | ENST00000584220 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
| intron-intron | ENST00000585812 | ENST00000582052 | BCAS3 | chr17 | 58786686 | + | ORMDL3 | chr17 | 38080478 | - |
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FusionProtFeatures for BCAS3_ORMDL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCAS3 | ORMDL3 |