|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39562 |
FusionGeneSummary for TRIM65_SRP68 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIM65_SRP68 | Fusion gene ID: 39562 | Hgene | Tgene | Gene symbol | TRIM65 | SRP68 | Gene ID | 201292 | 6730 |
| Gene name | tripartite motif containing 65 | signal recognition particle 68 | |
| Synonyms | 4732463G12Rik | - | |
| Cytomap | 17q25.1 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tripartite motif-containing protein 65 | signal recognition particle subunit SRP68signal recognition particle 68 kDa proteinsignal recognition particle 68kDsignal recognition particle 68kDa | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6PJ69 | Q9UHB9 | |
| Ensembl transtripts involved in fusion gene | ENST00000269383, | ENST00000307877, ENST00000539137, ENST00000355113, ENST00000602720, ENST00000542536, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 10 X 10 X 9=900 |
| # samples | 2 | 15 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(15/900*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIM65 [Title/Abstract] AND SRP68 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRP68 | GO:0042493 | response to drug | 18089836 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-60-2706-01A | TRIM65 | chr17 | 73887894 | - | SRP68 | chr17 | 74053624 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000269383 | ENST00000307877 | TRIM65 | chr17 | 73887894 | - | SRP68 | chr17 | 74053624 | - |
| Frame-shift | ENST00000269383 | ENST00000539137 | TRIM65 | chr17 | 73887894 | - | SRP68 | chr17 | 74053624 | - |
| Frame-shift | ENST00000269383 | ENST00000355113 | TRIM65 | chr17 | 73887894 | - | SRP68 | chr17 | 74053624 | - |
| 5CDS-intron | ENST00000269383 | ENST00000602720 | TRIM65 | chr17 | 73887894 | - | SRP68 | chr17 | 74053624 | - |
| 5CDS-intron | ENST00000269383 | ENST00000542536 | TRIM65 | chr17 | 73887894 | - | SRP68 | chr17 | 74053624 | - |
Top |
FusionProtFeatures for TRIM65_SRP68 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM65 | SRP68 |