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Fusion gene ID: 39560 |
FusionGeneSummary for TRIM63_PTMA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIM63_PTMA | Fusion gene ID: 39560 | Hgene | Tgene | Gene symbol | TRIM63 | PTMA | Gene ID | 84676 | 5757 |
| Gene name | tripartite motif containing 63 | prothymosin alpha | |
| Synonyms | IRF|MURF1|MURF2|RNF28|SMRZ | TMSA | |
| Cytomap | 1p36.11 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM63RING-type E3 ubiquitin transferase TRIM63iris ring finger proteinmuscle specific ring finger protein 2muscle-specific RING finger protein 1ring finger protein 28striated muscle RING zinc finger proteintripartite mo | prothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/- | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q969Q1 | P06454 | |
| Ensembl transtripts involved in fusion gene | ENST00000374272, ENST00000483052, | ENST00000466801, ENST00000409321, ENST00000409115, ENST00000341369, ENST00000409683, ENST00000410064, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 17 X 17 X 2=578 |
| # samples | 2 | 18 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(18/578*10)=-1.683072586171 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIM63 [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC015717 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000374272 | ENST00000466801 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| 5CDS-3UTR | ENST00000374272 | ENST00000409321 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| 5CDS-3UTR | ENST00000374272 | ENST00000409115 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| 5CDS-3UTR | ENST00000374272 | ENST00000341369 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| 5CDS-3UTR | ENST00000374272 | ENST00000409683 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| 5CDS-3UTR | ENST00000374272 | ENST00000410064 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| intron-3UTR | ENST00000483052 | ENST00000466801 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| intron-3UTR | ENST00000483052 | ENST00000409321 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| intron-3UTR | ENST00000483052 | ENST00000409115 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| intron-3UTR | ENST00000483052 | ENST00000341369 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| intron-3UTR | ENST00000483052 | ENST00000409683 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
| intron-3UTR | ENST00000483052 | ENST00000410064 | TRIM63 | chr1 | 26383698 | - | PTMA | chr2 | 232577207 | + |
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FusionProtFeatures for TRIM63_PTMA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM63 | PTMA |