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Fusion gene ID: 39515 |
FusionGeneSummary for TRIM33_BCAR3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIM33_BCAR3 | Fusion gene ID: 39515 | Hgene | Tgene | Gene symbol | TRIM33 | BCAR3 | Gene ID | 51592 | 8412 |
| Gene name | tripartite motif containing 33 | BCAR3, NSP family adaptor protein | |
| Synonyms | ECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMA | AND-34|NSP2|SH2D3B | |
| Cytomap | 1p13.2 | 1p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gamma | breast cancer anti-estrogen resistance protein 3SH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistance 3)novel SH2-containing protein | |
| Modification date | 20180520 | 20180519 | |
| UniProtAcc | Q9UPN9 | O75815 | |
| Ensembl transtripts involved in fusion gene | ENST00000358465, ENST00000369543, ENST00000450349, ENST00000476908, | ENST00000260502, ENST00000370244, ENST00000370243, ENST00000370247, ENST00000539242, ENST00000466632, | |
| Fusion gene scores | * DoF score | 11 X 8 X 9=792 | 5 X 4 X 3=60 |
| # samples | 12 | 5 | |
| ** MAII score | log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIM33 [Title/Abstract] AND BCAR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRIM33 | GO:0016567 | protein ubiquitination | 19135894 |
| Hgene | TRIM33 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 19135894 |
| Hgene | TRIM33 | GO:0030514 | negative regulation of BMP signaling pathway | 19135894 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-AG-4021-01A | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000358465 | ENST00000260502 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-5UTR | ENST00000358465 | ENST00000370244 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000358465 | ENST00000370243 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000358465 | ENST00000370247 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000358465 | ENST00000539242 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000358465 | ENST00000466632 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000369543 | ENST00000260502 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-5UTR | ENST00000369543 | ENST00000370244 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000369543 | ENST00000370243 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000369543 | ENST00000370247 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000369543 | ENST00000539242 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| 5CDS-intron | ENST00000369543 | ENST00000466632 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000450349 | ENST00000260502 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-5UTR | ENST00000450349 | ENST00000370244 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000450349 | ENST00000370243 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000450349 | ENST00000370247 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000450349 | ENST00000539242 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000450349 | ENST00000466632 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000476908 | ENST00000260502 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-5UTR | ENST00000476908 | ENST00000370244 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000476908 | ENST00000370243 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000476908 | ENST00000370247 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000476908 | ENST00000539242 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
| intron-intron | ENST00000476908 | ENST00000466632 | TRIM33 | chr1 | 115053172 | - | BCAR3 | chr1 | 94171698 | - |
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FusionProtFeatures for TRIM33_BCAR3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM33 | BCAR3 |