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Fusion gene ID: 39510

FusionGeneSummary for TRIM2_WDR37

Fusion gene summary

Fusion gene information	Fusion gene name: TRIM2_WDR37
	Fusion gene ID: 39510
		Hgene	Tgene
	Gene symbol	TRIM2	WDR37
	Gene ID	23321	22884
	Gene name	tripartite motif containing 2	WD repeat domain 37
	Synonyms	CMT2R\|RNF86	-
	Cytomap	4q31.3	10p15.3
	Type of gene	protein-coding	protein-coding
	Description	tripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2	WD repeat-containing protein 37
	Modification date	20180523	20180523
	UniProtAcc	Q9C040	Q9Y2I8
	Ensembl transtripts involved in fusion gene	ENST00000437508, ENST00000494872, ENST00000338700,	ENST00000358220, ENST00000381329, ENST00000263150, ENST00000482165,
Fusion gene scores	* DoF score	11 X 10 X 7=770	4 X 4 X 3=48
	# samples	14	4
	** MAII score	log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRIM2 [Title/Abstract] AND WDR37 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-E1-5304-01A	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000437508	ENST00000358220	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
intron-intron	ENST00000437508	ENST00000381329	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
intron-intron	ENST00000437508	ENST00000263150	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
intron-intron	ENST00000437508	ENST00000482165	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
3UTR-3CDS	ENST00000494872	ENST00000358220	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
3UTR-intron	ENST00000494872	ENST00000381329	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
3UTR-intron	ENST00000494872	ENST00000263150	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
3UTR-intron	ENST00000494872	ENST00000482165	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
In-frame	ENST00000338700	ENST00000358220	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
5CDS-intron	ENST00000338700	ENST00000381329	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
5CDS-intron	ENST00000338700	ENST00000263150	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+
5CDS-intron	ENST00000338700	ENST00000482165	TRIM2	chr4	154125712	+	WDR37	chr10	1149542	+

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FusionProtFeatures for TRIM2_WDR37

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TRIM2 Q9C040	WDR37 Q9Y2I8

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Fusion gene ID: 39510

FusionGeneSummary for TRIM2_WDR37

FusionProtFeatures for TRIM2_WDR37