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Fusion gene ID: 39458 |
FusionGeneSummary for TRIB1_SLC25A32 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIB1_SLC25A32 | Fusion gene ID: 39458 | Hgene | Tgene | Gene symbol | TRIB1 | SLC25A32 | Gene ID | 10221 | 81034 |
| Gene name | tribbles pseudokinase 1 | solute carrier family 25 member 32 | |
| Synonyms | C8FW|GIG-2|GIG2|SKIP1|TRB-1|TRB1 | MFT|MFTC|RREI | |
| Cytomap | 8q24.13 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tribbles homolog 1G-protein-coupled receptor induced proteinG-protein-coupled receptor-induced gene 2 proteinG-protein-coupled receptor-induced protein 2phosphoprotein regulated by mitogenic pathwaystribbles-like protein 1 | mitochondrial folate transporter/carriersolute carrier family 25 (mitochondrial folate carrier), member 32 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96RU8 | Q9H2D1 | |
| Ensembl transtripts involved in fusion gene | ENST00000311922, ENST00000520847, ENST00000521778, ENST00000519576, | ENST00000297578, ENST00000543107, ENST00000523701, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 2 X 3=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TRIB1 [Title/Abstract] AND SLC25A32 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRIB1 | GO:0043405 | regulation of MAP kinase activity | 15299019 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A105-01A | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000311922 | ENST00000297578 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5CDS-5UTR | ENST00000311922 | ENST00000543107 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5CDS-intron | ENST00000311922 | ENST00000523701 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| Frame-shift | ENST00000520847 | ENST00000297578 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5CDS-5UTR | ENST00000520847 | ENST00000543107 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5CDS-intron | ENST00000520847 | ENST00000523701 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| intron-3CDS | ENST00000521778 | ENST00000297578 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| intron-5UTR | ENST00000521778 | ENST00000543107 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| intron-intron | ENST00000521778 | ENST00000523701 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5UTR-3CDS | ENST00000519576 | ENST00000297578 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5UTR-5UTR | ENST00000519576 | ENST00000543107 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
| 5UTR-intron | ENST00000519576 | ENST00000523701 | TRIB1 | chr8 | 126445851 | + | SLC25A32 | chr8 | 104420012 | - |
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FusionProtFeatures for TRIB1_SLC25A32 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIB1 | SLC25A32 |