|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39434 |
FusionGeneSummary for TRDMT1_NID2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRDMT1_NID2 | Fusion gene ID: 39434 | Hgene | Tgene | Gene symbol | TRDMT1 | NID2 | Gene ID | 1787 | 22795 |
| Gene name | tRNA aspartic acid methyltransferase 1 | nidogen 2 | |
| Synonyms | DMNT2|DNMT2|MHSAIIP|PUMET|RNMT1 | NID-2 | |
| Cytomap | 10p13 | 14q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tRNA (cytosine(38)-C(5))-methyltransferaseDNA (cytosine-5)-methyltransferase-like protein 2DNA MTase homolog HsaIIPDNA cytosine-5 methyltransferase 2DNA methyltransferase-2tRNA (cytosine-5-)-methyltransferase | nidogen-2osteonidogen | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | O14717 | Q14112 | |
| Ensembl transtripts involved in fusion gene | ENST00000377799, ENST00000377766, ENST00000412821, ENST00000358282, ENST00000351358, ENST00000457442, ENST00000452380, ENST00000488990, | ENST00000541773, ENST00000216286, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 2=32 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/4*10)=3.90689059560852 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TRDMT1 [Title/Abstract] AND NID2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRDMT1 | GO:0030488 | tRNA methylation | 16424344 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA483206 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377799 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000377799 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| 3UTR-3CDS | ENST00000377766 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| 3UTR-3CDS | ENST00000377766 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000412821 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000412821 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| 3UTR-3CDS | ENST00000358282 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| 3UTR-3CDS | ENST00000358282 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000351358 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000351358 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000457442 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| In-frame | ENST00000457442 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| 5UTR-3CDS | ENST00000452380 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| 5UTR-3CDS | ENST00000452380 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| intron-3CDS | ENST00000488990 | ENST00000541773 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
| intron-3CDS | ENST00000488990 | ENST00000216286 | TRDMT1 | chr10 | 17195506 | - | NID2 | chr14 | 52486897 | - |
Top |
FusionProtFeatures for TRDMT1_NID2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRDMT1 | NID2 |