|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39373 |
FusionGeneSummary for TRAM1_RAP1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRAM1_RAP1A | Fusion gene ID: 39373 | Hgene | Tgene | Gene symbol | TRAM1 | RAP1A | Gene ID | 23471 | 5906 |
| Gene name | translocation associated membrane protein 1 | RAP1A, member of RAS oncogene family | |
| Synonyms | PNAS8|TRAM|TRAMP | C21KG|G-22K|KREV-1|KREV1|RAP1|SMGP21 | |
| Cytomap | 8q13.3 | 1p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | translocating chain-associated membrane protein 1translocating chain-associating membrane proteintranslocation-associating membrane protein 1 | ras-related protein Rap-1AGTP-binding protein smg p21ARas-related protein Krev-1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q15629 | P62834 | |
| Ensembl transtripts involved in fusion gene | ENST00000521425, ENST00000262213, ENST00000536748, ENST00000521049, | ENST00000356415, ENST00000436150, ENST00000369709, ENST00000545460, ENST00000494982, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 6 X 3=90 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRAM1 [Title/Abstract] AND RAP1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAP1A | GO:0015031 | protein transport | 17916086 |
| Tgene | RAP1A | GO:0071320 | cellular response to cAMP | 21840392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI207431 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000521425 | ENST00000356415 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521425 | ENST00000436150 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521425 | ENST00000369709 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-intron | ENST00000521425 | ENST00000545460 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521425 | ENST00000494982 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000262213 | ENST00000356415 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000262213 | ENST00000436150 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000262213 | ENST00000369709 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-intron | ENST00000262213 | ENST00000545460 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000262213 | ENST00000494982 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000536748 | ENST00000356415 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000536748 | ENST00000436150 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000536748 | ENST00000369709 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-intron | ENST00000536748 | ENST00000545460 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000536748 | ENST00000494982 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521049 | ENST00000356415 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521049 | ENST00000436150 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521049 | ENST00000369709 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-intron | ENST00000521049 | ENST00000545460 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
| intron-3UTR | ENST00000521049 | ENST00000494982 | TRAM1 | chr8 | 71516296 | + | RAP1A | chr1 | 112255277 | + |
Top |
FusionProtFeatures for TRAM1_RAP1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRAM1 | RAP1A |