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Fusion gene ID: 39315 |
FusionGeneSummary for TRABD2B_PKN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRABD2B_PKN2 | Fusion gene ID: 39315 | Hgene | Tgene | Gene symbol | TRABD2B | PKN2 | Gene ID | 388630 | 5586 |
| Gene name | TraB domain containing 2B | protein kinase N2 | |
| Synonyms | TIKI2 | PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7 | |
| Cytomap | 1p33 | 1p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metalloprotease TIKI2TRAB domain-containing protein 2BUPF0632 protein Aheart, kidney and adipose-enriched transmembrane protein homolog | serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2 | |
| Modification date | 20180403 | 20180523 | |
| UniProtAcc | A6NFA1 | Q16513 | |
| Ensembl transtripts involved in fusion gene | ENST00000606738, ENST00000435576, | ENST00000316005, ENST00000370521, ENST00000370505, ENST00000370513, ENST00000544045, ENST00000495119, | |
| Fusion gene scores | * DoF score | 7 X 3 X 5=105 | 4 X 2 X 3=24 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TRABD2B [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRABD2B | GO:0006508 | proteolysis | 22726442 |
| Hgene | TRABD2B | GO:0030178 | negative regulation of Wnt signaling pathway | 22726442 |
| Hgene | TRABD2B | GO:0032461 | positive regulation of protein oligomerization | 22726442 |
| Hgene | TRABD2B | GO:1904808 | positive regulation of protein oxidation | 22726442 |
| Tgene | PKN2 | GO:0006468 | protein phosphorylation | 17332740 |
| Tgene | PKN2 | GO:0010631 | epithelial cell migration | 21754995 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A5ZV-01A | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000606738 | ENST00000316005 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| In-frame | ENST00000606738 | ENST00000370521 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000370505 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000370513 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000544045 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000495119 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000316005 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000370521 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000370505 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000370513 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000544045 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000495119 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
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FusionProtFeatures for TRABD2B_PKN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRABD2B | PKN2 |