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Fusion gene ID: 39235 |
FusionGeneSummary for TPM3_KCNN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TPM3_KCNN3 | Fusion gene ID: 39235 | Hgene | Tgene | Gene symbol | TPM3 | KCNN3 | Gene ID | 7170 | 3782 |
| Gene name | tropomyosin 3 | potassium calcium-activated channel subfamily N member 3 | |
| Synonyms | CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30 | KCa2.3|SK3|SKCA3|hSK3 | |
| Cytomap | 1q21.3 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi | small conductance calcium-activated potassium channel protein 3SKCa 3potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3potassium intermediate/small conductance calcium-activated channel, subfamily N, member | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P06753 | Q9UGI6 | |
| Ensembl transtripts involved in fusion gene | ENST00000368533, ENST00000469717, ENST00000330188, ENST00000341485, ENST00000341372, ENST00000328159, ENST00000271850, ENST00000302206, ENST00000368531, ENST00000323144, ENST00000368530, | ENST00000271915, ENST00000361147, ENST00000358505, ENST00000515643, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 4 X 4 X 3=48 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/252*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TPM3 [Title/Abstract] AND KCNN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-IS-A3K6-01A | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000368533 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000368533 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000368533 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000368533 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000469717 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000469717 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000469717 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000469717 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000330188 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000330188 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000330188 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000330188 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000341485 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000341485 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000341485 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000341485 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000341372 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000341372 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000341372 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000341372 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| Frame-shift | ENST00000328159 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| Frame-shift | ENST00000328159 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| 5CDS-5UTR | ENST00000328159 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| 5CDS-intron | ENST00000328159 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000271850 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000271850 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000271850 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000271850 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000302206 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000302206 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000302206 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000302206 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000368531 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000368531 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000368531 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000368531 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000323144 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-3CDS | ENST00000323144 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-5UTR | ENST00000323144 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| intron-intron | ENST00000323144 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| Frame-shift | ENST00000368530 | ENST00000271915 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| Frame-shift | ENST00000368530 | ENST00000361147 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| 5CDS-5UTR | ENST00000368530 | ENST00000358505 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
| 5CDS-intron | ENST00000368530 | ENST00000515643 | TPM3 | chr1 | 154141781 | - | KCNN3 | chr1 | 154794660 | - |
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FusionProtFeatures for TPM3_KCNN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TPM3 | KCNN3 |