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Fusion gene ID: 39210 |
FusionGeneSummary for TPI1_MAPK14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TPI1_MAPK14 | Fusion gene ID: 39210 | Hgene | Tgene | Gene symbol | TPI1 | MAPK14 | Gene ID | 7167 | 1432 |
| Gene name | triosephosphate isomerase 1 | mitogen-activated protein kinase 14 | |
| Synonyms | HEL-S-49|TIM|TPI|TPID | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA | |
| Cytomap | 12p13.31 | 6p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | triosephosphate isomeraseepididymis secretory protein Li 49triose-phosphate isomerase | mitogen-activated protein kinase 14CSAID-binding proteinCsaids binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P60174 | Q16539 | |
| Ensembl transtripts involved in fusion gene | ENST00000229270, ENST00000396705, ENST00000488464, ENST00000535434, | ENST00000229795, ENST00000229794, ENST00000468133, ENST00000310795, | |
| Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 5 X 4 X 2=40 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/40*10)=0 | |
| Context | PubMed: TPI1 [Title/Abstract] AND MAPK14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAPK14 | GO:0035556 | intracellular signal transduction | 10838079 |
| Tgene | MAPK14 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
| Tgene | MAPK14 | GO:1900015 | regulation of cytokine production involved in inflammatory response | 15251176 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI652202 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000229270 | ENST00000229795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-3UTR | ENST00000229270 | ENST00000229794 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-intron | ENST00000229270 | ENST00000468133 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-intron | ENST00000229270 | ENST00000310795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-3UTR | ENST00000396705 | ENST00000229795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-3UTR | ENST00000396705 | ENST00000229794 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-intron | ENST00000396705 | ENST00000468133 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-intron | ENST00000396705 | ENST00000310795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| intron-3UTR | ENST00000488464 | ENST00000229795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| intron-3UTR | ENST00000488464 | ENST00000229794 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| intron-intron | ENST00000488464 | ENST00000468133 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| intron-intron | ENST00000488464 | ENST00000310795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-3UTR | ENST00000535434 | ENST00000229795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-3UTR | ENST00000535434 | ENST00000229794 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-intron | ENST00000535434 | ENST00000468133 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
| 3UTR-intron | ENST00000535434 | ENST00000310795 | TPI1 | chr12 | 6979938 | - | MAPK14 | chr6 | 36076833 | - |
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FusionProtFeatures for TPI1_MAPK14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TPI1 | MAPK14 |