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Fusion gene ID: 39177

FusionGeneSummary for TP63_TPRG1

Fusion gene summary

Fusion gene information	Fusion gene name: TP63_TPRG1
	Fusion gene ID: 39177
		Hgene	Tgene
	Gene symbol	TP63	TPRG1
	Gene ID	8626	285386
	Gene name	tumor protein p63	tumor protein p63 regulated 1
	Synonyms	AIS\|B(p51A)\|B(p51B)\|EEC3\|KET\|LMS\|NBP\|OFC8\|RHS\|SHFM4\|TP53CP\|TP53L\|TP73L\|p40\|p51\|p53CP\|p63\|p73H\|p73L	FAM79B
	Cytomap	3q28	3q28
	Type of gene	protein-coding	protein-coding
	Description	tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein	tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B
	Modification date	20180521	20180403
	UniProtAcc	Q9H3D4	Q6ZUI0
	Ensembl transtripts involved in fusion gene	ENST00000264731, ENST00000382063, ENST00000418709, ENST00000320472, ENST00000392460, ENST00000440651, ENST00000354600, ENST00000437221, ENST00000392463, ENST00000392461, ENST00000456148, ENST00000449992,	ENST00000433971, ENST00000345063, ENST00000488841,
Fusion gene scores	* DoF score	4 X 3 X 3=36	12 X 6 X 6=432
	# samples	4	13
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TP63 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TP63	GO:0045747	positive regulation of Notch signaling pathway	11641404
Hgene	TP63	GO:0045892	negative regulation of transcription, DNA-templated	12446784
Hgene	TP63	GO:0045893	positive regulation of transcription, DNA-templated	12446784\|16343436
Hgene	TP63	GO:0045944	positive regulation of transcription by RNA polymerase II	22521434
Hgene	TP63	GO:2000271	positive regulation of fibroblast apoptotic process	9774969

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-77-A5G7-01B	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000264731	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000264731	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000264731	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000382063	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000382063	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000382063	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000418709	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000418709	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000418709	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000320472	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000320472	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000320472	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000392460	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000392460	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000392460	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000440651	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
In-frame	ENST00000440651	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000440651	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000354600	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000354600	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000354600	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000437221	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000437221	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000437221	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000392463	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000392463	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000392463	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000392461	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000392461	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000392461	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000456148	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000456148	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000456148	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000449992	ENST00000433971	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000449992	ENST00000345063	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000449992	ENST00000488841	TP63	chr3	189349366	+	TPRG1	chr3	189028175	+

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FusionProtFeatures for TP63_TPRG1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TP63 Q9H3D4	TPRG1 Q6ZUI0

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Fusion gene ID: 39177

FusionGeneSummary for TP63_TPRG1

FusionProtFeatures for TP63_TPRG1