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Fusion gene ID: 39145 |
FusionGeneSummary for TP53INP1_CCDC144B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TP53INP1_CCDC144B | Fusion gene ID: 39145 | Hgene | Tgene | Gene symbol | TP53INP1 | CCDC144B | Gene ID | 94241 | 284047 |
| Gene name | tumor protein p53 inducible nuclear protein 1 | coiled-coil domain containing 144B (pseudogene) | |
| Synonyms | SIP|TP53DINP1|TP53INP1A|TP53INP1B|Teap|p53DINP1 | - | |
| Cytomap | 8q22.1 | 17p11.2 | |
| Type of gene | protein-coding | pseudo | |
| Description | tumor protein p53-inducible nuclear protein 1p53-dependent damage-inducible nuclear protein 1p53-inducible p53DINP1stress-induced protein | coiled-coil domain-containing protein 144B | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q96A56 | ||
| Ensembl transtripts involved in fusion gene | ENST00000448464, ENST00000342697, ENST00000378776, | ENST00000442583, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TP53INP1 [Title/Abstract] AND CCDC144B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TP53INP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 22470510 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-YL-A8SJ-01B | TP53INP1 | chr8 | 95942768 | - | CCDC144B | chr17 | 18457580 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000448464 | ENST00000442583 | TP53INP1 | chr8 | 95942768 | - | CCDC144B | chr17 | 18457580 | - |
| intron-intron | ENST00000342697 | ENST00000442583 | TP53INP1 | chr8 | 95942768 | - | CCDC144B | chr17 | 18457580 | - |
| intron-intron | ENST00000378776 | ENST00000442583 | TP53INP1 | chr8 | 95942768 | - | CCDC144B | chr17 | 18457580 | - |
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FusionProtFeatures for TP53INP1_CCDC144B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TP53INP1 | CCDC144B |