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Fusion gene ID: 39140 |
FusionGeneSummary for TP53BP2_RPL30 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TP53BP2_RPL30 | Fusion gene ID: 39140 | Hgene | Tgene | Gene symbol | TP53BP2 | RPL30 | Gene ID | 7159 | 6156 |
| Gene name | tumor protein p53 binding protein 2 | ribosomal protein L30 | |
| Synonyms | 53BP2|ASPP2|BBP|P53BP2|PPP1R13A | L30 | |
| Cytomap | 1q41 | 8q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apoptosis-stimulating of p53 protein 2BCL2-binding proteinapoptosis-stimulating protein of p53, 2renal carcinoma antigen NY-REN-51tumor suppressor p53-binding protein 2 | 60S ribosomal protein L30large ribosomal subunit protein eL30 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13625 | P62888 | |
| Ensembl transtripts involved in fusion gene | ENST00000391878, ENST00000343537, ENST00000391879, ENST00000498843, | ENST00000518164, ENST00000521291, ENST00000396070, ENST00000287038, ENST00000523172, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 10 X 7 X 5=350 |
| # samples | 3 | 15 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/350*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TP53BP2 [Title/Abstract] AND RPL30 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TP53BP2 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11684014 |
| Tgene | RPL30 | GO:0002181 | cytoplasmic translation | 25957688 |
| Tgene | RPL30 | GO:0031640 | killing of cells of other organism | 15019208 |
| Tgene | RPL30 | GO:0050829 | defense response to Gram-negative bacterium | 15019208 |
| Tgene | RPL30 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 15019208 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW662691 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000391878 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-intron | ENST00000391878 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391878 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391878 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391878 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000343537 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-intron | ENST00000343537 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000343537 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000343537 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000343537 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391879 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-intron | ENST00000391879 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391879 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391879 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000391879 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000498843 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-intron | ENST00000498843 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000498843 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000498843 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
| intron-5UTR | ENST00000498843 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
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FusionProtFeatures for TP53BP2_RPL30 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TP53BP2 | RPL30 |