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Fusion gene ID: 39106 |
FusionGeneSummary for TOPORS_SNHG8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOPORS_SNHG8 | Fusion gene ID: 39106 | Hgene | Tgene | Gene symbol | TOPORS | SNHG8 | Gene ID | 10210 | 100093630 |
| Gene name | TOP1 binding arginine/serine rich protein | small nucleolar RNA host gene 8 | |
| Synonyms | LUN|P53BP3|RP31|TP53BPL | LINC00060|NCRNA00060 | |
| Cytomap | 9p21.1 | 4q26 | |
| Type of gene | protein-coding | ncRNA | |
| Description | E3 ubiquitin-protein ligase ToporsRING-type E3 ubiquitin transferase ToporsSUMO1-protein E3 ligase Toporstopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligasetopoisomerase I-binding RING finger proteintumor suppressor p53-binding | long intergenic non-protein coding RNA 60small nucleolar RNA host gene (non-protein coding) 8small nucleolar RNA host gene 8 (non-protein coding) | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q9NS56 | ||
| Ensembl transtripts involved in fusion gene | ENST00000360538, ENST00000379858, | ENST00000384096, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TOPORS [Title/Abstract] AND SNHG8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOPORS | GO:0000209 | protein polyubiquitination | 15247280 |
| Hgene | TOPORS | GO:0006513 | protein monoubiquitination | 15247280 |
| Hgene | TOPORS | GO:0006974 | cellular response to DNA damage stimulus | 15735665 |
| Hgene | TOPORS | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 20188669 |
| Hgene | TOPORS | GO:0016925 | protein sumoylation | 17803295 |
| Hgene | TOPORS | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 15247280 |
| Hgene | TOPORS | GO:0051457 | maintenance of protein location in nucleus | 14516784 |
| Hgene | TOPORS | GO:0070936 | protein K48-linked ubiquitination | 15247280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF094191 | TOPORS | chr9 | 32543255 | - | SNHG8 | chr4 | 119199915 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000360538 | ENST00000384096 | TOPORS | chr9 | 32543255 | - | SNHG8 | chr4 | 119199915 | + |
| intron-intron | ENST00000379858 | ENST00000384096 | TOPORS | chr9 | 32543255 | - | SNHG8 | chr4 | 119199915 | + |
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FusionProtFeatures for TOPORS_SNHG8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOPORS | SNHG8 |