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Fusion gene ID: 39100 |
FusionGeneSummary for TOPBP1_CEP135 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOPBP1_CEP135 | Fusion gene ID: 39100 | Hgene | Tgene | Gene symbol | TOPBP1 | CEP135 | Gene ID | 11073 | 9662 |
| Gene name | DNA topoisomerase II binding protein 1 | centrosomal protein 135 | |
| Synonyms | TOP2BP1 | CEP4|KIAA0635|MCPH8 | |
| Cytomap | 3q22.1 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 2-binding protein 1DNA topoisomerase II-beta-binding protein 1topoisomerase (DNA) II binding protein 1 | centrosomal protein of 135 kDacentrosomal protein 135kDacentrosomal protein 4centrosome protein cep135 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q92547 | Q66GS9 | |
| Ensembl transtripts involved in fusion gene | ENST00000260810, ENST00000511439, | ENST00000257287, ENST00000422247, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TOPBP1 [Title/Abstract] AND CEP135 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOPBP1 | GO:0006974 | cellular response to DNA damage stimulus | 12773567 |
| Hgene | TOPBP1 | GO:0010212 | response to ionizing radiation | 12773567 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA704218 | TOPBP1 | chr3 | 133364745 | + | CEP135 | chr4 | 56898345 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000260810 | ENST00000257287 | TOPBP1 | chr3 | 133364745 | + | CEP135 | chr4 | 56898345 | - |
| intron-intron | ENST00000260810 | ENST00000422247 | TOPBP1 | chr3 | 133364745 | + | CEP135 | chr4 | 56898345 | - |
| intron-3UTR | ENST00000511439 | ENST00000257287 | TOPBP1 | chr3 | 133364745 | + | CEP135 | chr4 | 56898345 | - |
| intron-intron | ENST00000511439 | ENST00000422247 | TOPBP1 | chr3 | 133364745 | + | CEP135 | chr4 | 56898345 | - |
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FusionProtFeatures for TOPBP1_CEP135 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOPBP1 | CEP135 |