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Fusion gene ID: 39096 |
FusionGeneSummary for TOP3A_TEKT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP3A_TEKT1 | Fusion gene ID: 39096 | Hgene | Tgene | Gene symbol | TOP3A | TEKT1 | Gene ID | 7156 | 83659 |
| Gene name | DNA topoisomerase III alpha | tektin 1 | |
| Synonyms | TOP3|ZGRF7 | - | |
| Cytomap | 17p11.2 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 3-alphatopo III-alphatopoisomerase (DNA) III alphazinc finger, GRF-type containing 7 | tektin-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13472 | Q969V4 | |
| Ensembl transtripts involved in fusion gene | ENST00000321105, ENST00000540524, ENST00000542570, ENST00000582230, | ENST00000338694, ENST00000535086, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 5 X 4 X 4=80 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP3A [Title/Abstract] AND TEKT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP3A | GO:0006265 | DNA topological change | 20445207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A6IX-01A | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| TCGA | RV | BRCA | TCGA-AC-A6IX-06A | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000321105 | ENST00000338694 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| 5CDS-5UTR | ENST00000321105 | ENST00000535086 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| intron-3CDS | ENST00000540524 | ENST00000338694 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| intron-5UTR | ENST00000540524 | ENST00000535086 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| 5UTR-3CDS | ENST00000542570 | ENST00000338694 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| 5UTR-5UTR | ENST00000542570 | ENST00000535086 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| 5UTR-3CDS | ENST00000582230 | ENST00000338694 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
| 5UTR-5UTR | ENST00000582230 | ENST00000535086 | TOP3A | chr17 | 18217913 | - | TEKT1 | chr17 | 6719281 | - |
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FusionProtFeatures for TOP3A_TEKT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP3A | TEKT1 |