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Fusion gene ID: 39090

FusionGeneSummary for TOP2B_SIMC1

Fusion gene summary

Fusion gene information	Fusion gene name: TOP2B_SIMC1
	Fusion gene ID: 39090
		Hgene	Tgene
	Gene symbol	TOP2B	SIMC1
	Gene ID	7155	375484
	Gene name	DNA topoisomerase II beta	SUMO interacting motifs containing 1
	Synonyms	TOPIIB\|top2beta	C5orf25\|OOMA1\|PLEIAD
	Cytomap	3p24.2	5q35.2
	Type of gene	protein-coding	protein-coding
	Description	DNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIb	SUMO-interacting motif-containing protein 1oocyte maturation associated 1platform element for inhibition of autolytic degradation
	Modification date	20180523	20180523
	UniProtAcc	Q02880	Q8NDZ2
	Ensembl transtripts involved in fusion gene	ENST00000435706, ENST00000264331, ENST00000542520, ENST00000540199, ENST00000475717,	ENST00000341199, ENST00000430704, ENST00000443967, ENST00000332772, ENST00000429602, ENST00000503595,
Fusion gene scores	* DoF score	5 X 6 X 3=90	2 X 2 X 2=8
	# samples	6	2
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: TOP2B [Title/Abstract] AND SIMC1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TOP2B	GO:0006265	DNA topological change	10684600

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BC037411	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000435706	ENST00000341199	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000435706	ENST00000430704	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000435706	ENST00000443967	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000435706	ENST00000332772	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000435706	ENST00000429602	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000435706	ENST00000503595	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000264331	ENST00000341199	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000264331	ENST00000430704	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000264331	ENST00000443967	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000264331	ENST00000332772	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000264331	ENST00000429602	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000264331	ENST00000503595	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000542520	ENST00000341199	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000542520	ENST00000430704	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000542520	ENST00000443967	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000542520	ENST00000332772	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000542520	ENST00000429602	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000542520	ENST00000503595	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000540199	ENST00000341199	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000540199	ENST00000430704	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000540199	ENST00000443967	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000540199	ENST00000332772	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000540199	ENST00000429602	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000540199	ENST00000503595	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000475717	ENST00000341199	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000475717	ENST00000430704	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000475717	ENST00000443967	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000475717	ENST00000332772	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-5UTR	ENST00000475717	ENST00000429602	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+
intron-intron	ENST00000475717	ENST00000503595	TOP2B	chr3	25706026	-	SIMC1	chr5	175665471	+

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FusionProtFeatures for TOP2B_SIMC1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TOP2B Q02880	SIMC1 Q8NDZ2

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Fusion gene ID: 39090

FusionGeneSummary for TOP2B_SIMC1

FusionProtFeatures for TOP2B_SIMC1