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Fusion gene ID: 39086 |
FusionGeneSummary for TOP2A_TNS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP2A_TNS4 | Fusion gene ID: 39086 | Hgene | Tgene | Gene symbol | TOP2A | TNS4 | Gene ID | 7153 | 84951 |
| Gene name | DNA topoisomerase II alpha | tensin 4 | |
| Synonyms | TOP2|TP2A | CTEN|PP14434 | |
| Cytomap | 17q21.2 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDa | tensin-4C terminal tensin likeC-terminal tensin-like protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P11388 | Q8IZW8 | |
| Ensembl transtripts involved in fusion gene | ENST00000423485, | ENST00000254051, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 3=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP2A [Title/Abstract] AND TNS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP2A | GO:0006265 | DNA topological change | 22323612 |
| Hgene | TOP2A | GO:0006266 | DNA ligation | 15491148 |
| Hgene | TOP2A | GO:0006974 | cellular response to DNA damage stimulus | 16611985 |
| Hgene | TOP2A | GO:0030263 | apoptotic chromosome condensation | 10959840 |
| Hgene | TOP2A | GO:0043065 | positive regulation of apoptotic process | 16611985 |
| Tgene | TNS4 | GO:0008104 | protein localization | 17190795 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-PC-A5DO-01A | TOP2A | chr17 | 38545768 | - | TNS4 | chr17 | 38640861 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000423485 | ENST00000254051 | TOP2A | chr17 | 38545768 | - | TNS4 | chr17 | 38640861 | - |
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FusionProtFeatures for TOP2A_TNS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP2A | TNS4 |