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Fusion gene ID: 39071 |
FusionGeneSummary for TOMM7_KLK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOMM7_KLK2 | Fusion gene ID: 39071 | Hgene | Tgene | Gene symbol | TOMM7 | KLK2 | Gene ID | 54543 | 3817 |
| Gene name | translocase of outer mitochondrial membrane 7 | kallikrein related peptidase 2 | |
| Synonyms | TOM7 | KLK2A2|hGK-1|hK2 | |
| Cytomap | 7p15.3 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitochondrial import receptor subunit TOM7 homolog6.2 kd proteintranslocase of outer membrane 7 kDa subunit homologtranslocase of outer mitochondrial membrane 7 homolog | kallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9P0U1 | P20151 | |
| Ensembl transtripts involved in fusion gene | ENST00000463284, ENST00000358435, ENST00000405021, ENST00000372879, | ENST00000325321, ENST00000391810, ENST00000358049, ENST00000597509, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 3 X 2=24 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TOMM7 [Title/Abstract] AND KLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A6E4-01A | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000463284 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-5UTR | ENST00000463284 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-intron | ENST00000463284 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-intron | ENST00000463284 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-5UTR | ENST00000358435 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-5UTR | ENST00000358435 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-intron | ENST00000358435 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| intron-intron | ENST00000358435 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-5UTR | ENST00000405021 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-5UTR | ENST00000405021 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-intron | ENST00000405021 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-intron | ENST00000405021 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-5UTR | ENST00000372879 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-5UTR | ENST00000372879 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-intron | ENST00000372879 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
| 5CDS-intron | ENST00000372879 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
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FusionProtFeatures for TOMM7_KLK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOMM7 | KLK2 |