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Fusion gene ID: 38997

FusionGeneSummary for TNRC6C_PLCB4

Fusion gene summary

Fusion gene information	Fusion gene name: TNRC6C_PLCB4
	Fusion gene ID: 38997
		Hgene	Tgene
	Gene symbol	TNRC6C	PLCB4
	Gene ID	57690	5332
	Gene name	trinucleotide repeat containing 6C	phospholipase C beta 4
	Synonyms	-	ARCND2\|PI-PLC
	Cytomap	17q25.3	20p12.3-p12.2
	Type of gene	protein-coding	protein-coding
	Description	trinucleotide repeat-containing gene 6C protein	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-41-phosphatidyl-D-myo-inositol-4,5-bisphosphatePLC-beta-4dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))inositoltrisphosphohydrolase
	Modification date	20180519	20180519
	UniProtAcc	Q9HCJ0	Q15147
	Ensembl transtripts involved in fusion gene	ENST00000588847, ENST00000588061, ENST00000335749, ENST00000301624, ENST00000541771, ENST00000544502,	ENST00000334005, ENST00000378473, ENST00000278655, ENST00000414679, ENST00000492632, ENST00000378501, ENST00000378493,
Fusion gene scores	* DoF score	7 X 6 X 4=168	5 X 5 X 2=50
	# samples	8	5
	** MAII score	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/50*10)=0
Context	PubMed: TNRC6C [Title/Abstract] AND PLCB4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNRC6C	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21984185
Hgene	TNRC6C	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21984185

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-A2-A1FW-01A	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000588847	ENST00000334005	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588847	ENST00000378473	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588847	ENST00000278655	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588847	ENST00000414679	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000588847	ENST00000492632	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000588847	ENST00000378501	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000588847	ENST00000378493	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588061	ENST00000334005	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588061	ENST00000378473	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588061	ENST00000278655	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000588061	ENST00000414679	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000588061	ENST00000492632	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000588061	ENST00000378501	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000588061	ENST00000378493	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000335749	ENST00000334005	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000335749	ENST00000378473	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000335749	ENST00000278655	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000335749	ENST00000414679	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000335749	ENST00000492632	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000335749	ENST00000378501	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000335749	ENST00000378493	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000301624	ENST00000334005	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000301624	ENST00000378473	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000301624	ENST00000278655	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000301624	ENST00000414679	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000301624	ENST00000492632	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000301624	ENST00000378501	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000301624	ENST00000378493	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000541771	ENST00000334005	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000541771	ENST00000378473	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000541771	ENST00000278655	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000541771	ENST00000414679	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000541771	ENST00000492632	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000541771	ENST00000378501	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000541771	ENST00000378493	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000544502	ENST00000334005	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000544502	ENST00000378473	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000544502	ENST00000278655	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
In-frame	ENST00000544502	ENST00000414679	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000544502	ENST00000492632	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000544502	ENST00000378501	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+
5CDS-3UTR	ENST00000544502	ENST00000378493	TNRC6C	chr17	76079247	+	PLCB4	chr20	9433994	+

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FusionProtFeatures for TNRC6C_PLCB4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TNRC6C Q9HCJ0	PLCB4 Q15147

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Fusion gene ID: 38997

FusionGeneSummary for TNRC6C_PLCB4

FusionProtFeatures for TNRC6C_PLCB4