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Fusion gene ID: 38972 |
FusionGeneSummary for TNRC6A_PRKCB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC6A_PRKCB | Fusion gene ID: 38972 | Hgene | Tgene | Gene symbol | TNRC6A | PRKCB | Gene ID | 27327 | 5579 |
| Gene name | trinucleotide repeat containing 6A | protein kinase C beta | |
| Synonyms | CAGH26|GW1|GW182|TNRC6 | PKC-beta|PKCB|PRKCB1|PRKCB2 | |
| Cytomap | 16p12.1 | 16p12.2-p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8NDV7 | P05771 | |
| Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000321728, ENST00000303531, ENST00000482000, ENST00000498058, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 13 X 9 X 10=1170 |
| # samples | 7 | 14 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1170*10)=-3.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNRC6A [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
| Tgene | PRKCB | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0882-01A | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315183 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| In-frame | ENST00000315183 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000315183 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000315183 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-intron | ENST00000562829 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-intron | ENST00000562829 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| In-frame | ENST00000395799 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| In-frame | ENST00000395799 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000395799 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000395799 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-3CDS | ENST00000432286 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-3CDS | ENST00000432286 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-intron | ENST00000432286 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-intron | ENST00000432286 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
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FusionProtFeatures for TNRC6A_PRKCB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC6A | PRKCB |