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Fusion gene ID: 38971 |
FusionGeneSummary for TNRC6A_METTL9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC6A_METTL9 | Fusion gene ID: 38971 | Hgene | Tgene | Gene symbol | TNRC6A | METTL9 | Gene ID | 27327 | 51108 |
| Gene name | trinucleotide repeat containing 6A | methyltransferase like 9 | |
| Synonyms | CAGH26|GW1|GW182|TNRC6 | CGI-81|DREV|DREV1|PAP1 | |
| Cytomap | 16p12.1 | 16p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | methyltransferase-like protein 9CTB-31N19.3DORA reverse strand protein 1p53 activated protein 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8NDV7 | Q9H1A3 | |
| Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000358154, ENST00000396014, ENST00000563026, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TNRC6A [Title/Abstract] AND METTL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-O2-A52S-01A | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315183 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| Frame-shift | ENST00000315183 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 5CDS-intron | ENST00000315183 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 3UTR-intron | ENST00000562829 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| In-frame | ENST00000395799 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| Frame-shift | ENST00000395799 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 5CDS-intron | ENST00000395799 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| intron-3CDS | ENST00000432286 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| intron-3CDS | ENST00000432286 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| intron-intron | ENST00000432286 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
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FusionProtFeatures for TNRC6A_METTL9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC6A | METTL9 |