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Fusion gene ID: 38957 |
FusionGeneSummary for TNRC18_HDAC9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC18_HDAC9 | Fusion gene ID: 38957 | Hgene | Tgene | Gene symbol | TNRC18 | HDAC9 | Gene ID | 84629 | 9734 |
| Gene name | trinucleotide repeat containing 18 | histone deacetylase 9 | |
| Synonyms | CAGL79|TNRC18A | HD7|HD7b|HD9|HDAC|HDAC7|HDAC7B|HDAC9B|HDAC9FL|HDRP|MITR | |
| Cytomap | 7p22.1 | 7p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 protein | histone deacetylase 9MEF-2 interacting transcription repressor (MITR) proteinhistone deacetylase 4/5-related proteinhistone deacetylase 7B | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O15417 | Q9UKV0 | |
| Ensembl transtripts involved in fusion gene | ENST00000399537, ENST00000430969, ENST00000399434, | ENST00000406451, ENST00000401921, ENST00000432645, ENST00000441542, ENST00000417496, ENST00000476135, ENST00000405010, ENST00000428307, ENST00000406072, ENST00000456174, ENST00000524023, | |
| Fusion gene scores | * DoF score | 16 X 15 X 8=1920 | 6 X 4 X 4=96 |
| # samples | 25 | 5 | |
| ** MAII score | log2(25/1920*10)=-2.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/96*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNRC18 [Title/Abstract] AND HDAC9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HDAC9 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10655483|11535832 |
| Tgene | HDAC9 | GO:0016575 | histone deacetylation | 11535832 |
| Tgene | HDAC9 | GO:0032869 | cellular response to insulin stimulus | 19303849 |
| Tgene | HDAC9 | GO:0034983 | peptidyl-lysine deacetylation | 11535832 |
| Tgene | HDAC9 | GO:0045892 | negative regulation of transcription, DNA-templated | 11535832 |
| Tgene | HDAC9 | GO:0070932 | histone H3 deacetylation | 12590135 |
| Tgene | HDAC9 | GO:0070933 | histone H4 deacetylation | 12590135 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-DA-A1HW-06A | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| TCGA | LD | SKCM | TCGA-DA-A1HW-06A | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000399537 | ENST00000406451 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000399537 | ENST00000401921 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000399537 | ENST00000432645 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000399537 | ENST00000441542 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000399537 | ENST00000417496 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-3UTR | ENST00000399537 | ENST00000476135 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000399537 | ENST00000405010 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000399537 | ENST00000428307 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000399537 | ENST00000406072 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000399537 | ENST00000456174 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000399537 | ENST00000524023 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000430969 | ENST00000406451 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000430969 | ENST00000401921 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000430969 | ENST00000432645 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000430969 | ENST00000441542 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000430969 | ENST00000417496 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-3UTR | ENST00000430969 | ENST00000476135 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000430969 | ENST00000405010 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000430969 | ENST00000428307 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-5UTR | ENST00000430969 | ENST00000406072 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000430969 | ENST00000456174 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000430969 | ENST00000524023 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-5UTR | ENST00000399434 | ENST00000406451 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-5UTR | ENST00000399434 | ENST00000401921 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-intron | ENST00000399434 | ENST00000432645 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-intron | ENST00000399434 | ENST00000441542 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-intron | ENST00000399434 | ENST00000417496 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-3UTR | ENST00000399434 | ENST00000476135 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-5UTR | ENST00000399434 | ENST00000405010 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-5UTR | ENST00000399434 | ENST00000428307 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-5UTR | ENST00000399434 | ENST00000406072 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-intron | ENST00000399434 | ENST00000456174 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| intron-intron | ENST00000399434 | ENST00000524023 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18535885 | + |
| 5CDS-intron | ENST00000399537 | ENST00000406451 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000401921 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000432645 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000441542 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000417496 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000476135 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000405010 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000428307 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000406072 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000456174 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000399537 | ENST00000524023 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000406451 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000401921 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000432645 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000441542 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000417496 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000476135 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000405010 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000428307 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000406072 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000456174 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| 5CDS-intron | ENST00000430969 | ENST00000524023 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000406451 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000401921 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000432645 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000441542 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000417496 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000476135 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000405010 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000428307 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000406072 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000456174 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
| intron-intron | ENST00000399434 | ENST00000524023 | TNRC18 | chr7 | 5401528 | - | HDAC9 | chr7 | 18365135 | + |
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FusionProtFeatures for TNRC18_HDAC9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC18 | HDAC9 |