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Fusion gene ID: 38913 |
FusionGeneSummary for TNKS_ASAH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNKS_ASAH1 | Fusion gene ID: 38913 | Hgene | Tgene | Gene symbol | TNKS | ASAH1 | Gene ID | 8658 | 427 |
| Gene name | tankyrase | N-acylsphingosine amidohydrolase 1 | |
| Synonyms | ARTD5|PARP-5a|PARP5A|PARPL|TIN1|TINF1|TNKS1|pART5 | AC|ACDase|ASAH|PHP|PHP32|SMAPME | |
| Cytomap | 8p23.1 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tankyrase-1ADP-ribosyltransferase diphtheria toxin-like 5TANK1TNKS-1TRF1-interacting ankyrin-related ADP-ribose polymerase 1poly [ADP-ribose] polymerase 5Atankyrase Itankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | acid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein | |
| Modification date | 20180523 | 20180529 | |
| UniProtAcc | O95271 | Q13510 | |
| Ensembl transtripts involved in fusion gene | ENST00000520408, ENST00000310430, ENST00000518281, ENST00000522110, ENST00000518027, | ENST00000262097, ENST00000381733, ENST00000417108, ENST00000520781, ENST00000314146, ENST00000520051, | |
| Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 6 X 6 X 5=180 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNKS [Title/Abstract] AND ASAH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNKS | GO:0000209 | protein polyubiquitination | 19759537|21478859 |
| Hgene | TNKS | GO:0006471 | protein ADP-ribosylation | 9822378|15133513|21270334 |
| Hgene | TNKS | GO:0018105 | peptidyl-serine phosphorylation | 17026964 |
| Hgene | TNKS | GO:0018107 | peptidyl-threonine phosphorylation | 17026964 |
| Hgene | TNKS | GO:0032212 | positive regulation of telomere maintenance via telomerase | 12782650|18221737 |
| Hgene | TNKS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19245366 |
| Hgene | TNKS | GO:0051973 | positive regulation of telomerase activity | 12782650 |
| Hgene | TNKS | GO:0070212 | protein poly-ADP-ribosylation | 9822378|16076287 |
| Hgene | TNKS | GO:0070213 | protein auto-ADP-ribosylation | 9822378|15133513|19759537|21478859 |
| Hgene | TNKS | GO:1904355 | positive regulation of telomere capping | 21531765 |
| Hgene | TNKS | GO:1904743 | negative regulation of telomeric DNA binding | 9822378 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A27N-01A | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000520408 | ENST00000262097 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| In-frame | ENST00000520408 | ENST00000381733 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000520408 | ENST00000417108 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000520408 | ENST00000520781 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000520408 | ENST00000314146 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000520408 | ENST00000520051 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| In-frame | ENST00000310430 | ENST00000262097 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| In-frame | ENST00000310430 | ENST00000381733 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000310430 | ENST00000417108 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000310430 | ENST00000520781 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000310430 | ENST00000314146 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000310430 | ENST00000520051 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| In-frame | ENST00000518281 | ENST00000262097 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| In-frame | ENST00000518281 | ENST00000381733 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000518281 | ENST00000417108 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000518281 | ENST00000520781 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000518281 | ENST00000314146 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 5CDS-intron | ENST00000518281 | ENST00000520051 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| intron-3CDS | ENST00000522110 | ENST00000262097 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| intron-3CDS | ENST00000522110 | ENST00000381733 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| intron-intron | ENST00000522110 | ENST00000417108 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| intron-intron | ENST00000522110 | ENST00000520781 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| intron-intron | ENST00000522110 | ENST00000314146 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| intron-intron | ENST00000522110 | ENST00000520051 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 3UTR-3CDS | ENST00000518027 | ENST00000262097 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 3UTR-3CDS | ENST00000518027 | ENST00000381733 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 3UTR-intron | ENST00000518027 | ENST00000417108 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 3UTR-intron | ENST00000518027 | ENST00000520781 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 3UTR-intron | ENST00000518027 | ENST00000314146 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
| 3UTR-intron | ENST00000518027 | ENST00000520051 | TNKS | chr8 | 9473187 | + | ASAH1 | chr8 | 17922040 | - |
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FusionProtFeatures for TNKS_ASAH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNKS | ASAH1 |