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Fusion gene ID: 38891 |
FusionGeneSummary for TNIP1_ARSI |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNIP1_ARSI | Fusion gene ID: 38891 | Hgene | Tgene | Gene symbol | TNIP1 | ARSI | Gene ID | 10318 | 340075 |
| Gene name | TNFAIP3 interacting protein 1 | arylsulfatase family member I | |
| Synonyms | ABIN-1|NAF1|VAN|nip40-1 | ASI|SPG66 | |
| Cytomap | 5q33.1 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein | arylsulfatase I | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q15025 | Q5FYB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000520931, ENST00000389378, ENST00000523338, ENST00000315050, ENST00000522226, ENST00000518977, ENST00000521591, ENST00000524280, ENST00000523200, ENST00000521423, | ENST00000328668, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/112*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TNIP1 [Title/Abstract] AND ARSI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNIP1 | GO:0009101 | glycoprotein biosynthetic process | 9923610 |
| Hgene | TNIP1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 16684768 |
| Hgene | TNIP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12220502 |
| Hgene | TNIP1 | GO:0085032 | modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade | 20010814 |
| Hgene | TNIP1 | GO:1903003 | positive regulation of protein deubiquitination | 16684768 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4965-01A | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000520931 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000389378 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000523338 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000315050 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| In-frame | ENST00000522226 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| In-frame | ENST00000518977 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| In-frame | ENST00000521591 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000524280 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| Frame-shift | ENST00000523200 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
| intron-3CDS | ENST00000521423 | ENST00000328668 | TNIP1 | chr5 | 150439879 | - | ARSI | chr5 | 149678175 | - |
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FusionProtFeatures for TNIP1_ARSI |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNIP1 | ARSI |