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Fusion gene ID: 38884 |
FusionGeneSummary for TNIK_DGCR8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNIK_DGCR8 | Fusion gene ID: 38884 | Hgene | Tgene | Gene symbol | TNIK | DGCR8 | Gene ID | 23043 | 54487 |
| Gene name | TRAF2 and NCK interacting kinase | DGCR8, microprocessor complex subunit | |
| Synonyms | MRT54 | C22orf12|DGCRK6|Gy1|pasha | |
| Cytomap | 3q26.2-q26.31 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TRAF2 and NCK-interacting protein kinase | microprocessor complex subunit DGCR8DiGeorge syndrome critical region 8DiGeorge syndrome critical region gene 8 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9UKE5 | Q8WYQ5 | |
| Ensembl transtripts involved in fusion gene | ENST00000436636, ENST00000538048, ENST00000369326, ENST00000341852, ENST00000284483, ENST00000470834, ENST00000460047, ENST00000475336, ENST00000488470, ENST00000357327, ENST00000464785, ENST00000465393, | ENST00000351989, ENST00000383024, ENST00000407755, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 6 X 5 X 4=120 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/150*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNIK [Title/Abstract] AND DGCR8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNIK | GO:0006468 | protein phosphorylation | 10521462|15342639|22797597 |
| Hgene | TNIK | GO:0007256 | activation of JNKK activity | 15342639 |
| Hgene | TNIK | GO:0031532 | actin cytoskeleton reorganization | 15342639 |
| Hgene | TNIK | GO:0035556 | intracellular signal transduction | 10521462 |
| Hgene | TNIK | GO:0046777 | protein autophosphorylation | 10521462|15342639 |
| Hgene | TNIK | GO:0048814 | regulation of dendrite morphogenesis | 20159449 |
| Tgene | DGCR8 | GO:0031053 | primary miRNA processing | 15531877|15574589|24449907|24910438 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TM-A84B-01A | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000436636 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000436636 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000436636 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000538048 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000538048 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000538048 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000369326 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000369326 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000369326 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000341852 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000341852 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000341852 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000284483 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000284483 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000284483 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000470834 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000470834 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000470834 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000460047 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000460047 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000460047 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000475336 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000475336 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000475336 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000488470 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000488470 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000488470 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000357327 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000357327 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| Frame-shift | ENST00000357327 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| intron-3CDS | ENST00000464785 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| intron-3CDS | ENST00000464785 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| intron-3CDS | ENST00000464785 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| intron-3CDS | ENST00000465393 | ENST00000351989 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| intron-3CDS | ENST00000465393 | ENST00000383024 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
| intron-3CDS | ENST00000465393 | ENST00000407755 | TNIK | chr3 | 170841385 | - | DGCR8 | chr22 | 20093700 | + |
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FusionProtFeatures for TNIK_DGCR8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNIK | DGCR8 |