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Fusion gene ID: 38874 |
FusionGeneSummary for TNFSF10_TNFSF10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNFSF10_TNFSF10 | Fusion gene ID: 38874 | Hgene | Tgene | Gene symbol | TNFSF10 | TNFSF10 | Gene ID | 8743 | 8743 |
| Gene name | TNF superfamily member 10 | TNF superfamily member 10 | |
| Synonyms | APO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL | APO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL | |
| Cytomap | 3q26.31 | 3q26.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superf | tumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superf | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P50591 | P50591 | |
| Ensembl transtripts involved in fusion gene | ENST00000241261, ENST00000420541, | ENST00000241261, ENST00000420541, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 5 X 4 X 4=80 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNFSF10 [Title/Abstract] AND TNFSF10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNFSF10 | GO:0043065 | positive regulation of apoptotic process | 21525171 |
| Hgene | TNFSF10 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 21459798|21525171|22266862 |
| Hgene | TNFSF10 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 22266862 |
| Hgene | TNFSF10 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 20097879|21525171|22266862 |
| Tgene | TNFSF10 | GO:0043065 | positive regulation of apoptotic process | 21525171 |
| Tgene | TNFSF10 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 21459798|21525171|22266862 |
| Tgene | TNFSF10 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 22266862 |
| Tgene | TNFSF10 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 20097879|21525171|22266862 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU674610 | TNFSF10 | chr3 | 172224429 | + | TNFSF10 | chr3 | 172224582 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000241261 | ENST00000241261 | TNFSF10 | chr3 | 172224429 | + | TNFSF10 | chr3 | 172224582 | - |
| intron-3UTR | ENST00000241261 | ENST00000420541 | TNFSF10 | chr3 | 172224429 | + | TNFSF10 | chr3 | 172224582 | - |
| intron-3CDS | ENST00000420541 | ENST00000241261 | TNFSF10 | chr3 | 172224429 | + | TNFSF10 | chr3 | 172224582 | - |
| intron-3UTR | ENST00000420541 | ENST00000420541 | TNFSF10 | chr3 | 172224429 | + | TNFSF10 | chr3 | 172224582 | - |
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FusionProtFeatures for TNFSF10_TNFSF10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNFSF10 | TNFSF10 |