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Fusion gene ID: 38864 |
FusionGeneSummary for TNFRSF1B_FBXO6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNFRSF1B_FBXO6 | Fusion gene ID: 38864 | Hgene | Tgene | Gene symbol | TNFRSF1B | FBXO6 | Gene ID | 7133 | 26270 |
| Gene name | TNF receptor superfamily member 1B | F-box protein 6 | |
| Synonyms | CD120b|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR1B|TNFR2|TNFR80|p75|p75TNFR | FBG2|FBS2|FBX6|Fbx6b | |
| Cytomap | 1p36.22 | 1p36.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor necrosis factor receptor superfamily member 1BTNF-R2TNF-RIIp75 TNF receptorp80 TNF-alpha receptorsoluble TNFR1B variant 1tumor necrosis factor beta receptortumor necrosis factor binding protein 2tumor necrosis factor receptor 2tumor necrosi | F-box only protein 6F-box protein FBG2F-box protein Fbx6F-box protein that recognizes sugar chains 2F-box/G-domain protein 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P20333 | Q9NRD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000536782, ENST00000492361, ENST00000376259, | ENST00000376753, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TNFRSF1B [Title/Abstract] AND FBXO6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FBXO6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 19716789 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D3-A51E-06A | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000536782 | ENST00000376753 | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
| 3UTR-3CDS | ENST00000492361 | ENST00000376753 | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
| Frame-shift | ENST00000376259 | ENST00000376753 | TNFRSF1B | chr1 | 12227226 | + | FBXO6 | chr1 | 11733334 | + |
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FusionProtFeatures for TNFRSF1B_FBXO6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNFRSF1B | FBXO6 |