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Fusion gene ID: 38830 |
FusionGeneSummary for TMX3_METTL4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMX3_METTL4 | Fusion gene ID: 38830 | Hgene | Tgene | Gene symbol | TMX3 | METTL4 | Gene ID | 54495 | 64863 |
| Gene name | thioredoxin related transmembrane protein 3 | methyltransferase like 4 | |
| Synonyms | PDIA13|TXNDC10 | HsT661 | |
| Cytomap | 18q22.1 | 18p11.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein disulfide-isomerase TMX3protein disulfide isomerase family A, member 13thioredoxin domain containing 10thioredoxin domain-containing protein 10 | methyltransferase-like protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96JJ7 | Q8N3J2 | |
| Ensembl transtripts involved in fusion gene | ENST00000299608, ENST00000566887, ENST00000443099, ENST00000562706, | ENST00000319888, ENST00000574538, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 2 X 4=48 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TMX3 [Title/Abstract] AND METTL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMX3 | GO:0018171 | peptidyl-cysteine oxidation | 15623505 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-21-1083-01A | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000299608 | ENST00000319888 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| 5CDS-5UTR | ENST00000299608 | ENST00000574538 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| intron-5UTR | ENST00000566887 | ENST00000319888 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| intron-5UTR | ENST00000566887 | ENST00000574538 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| 5CDS-5UTR | ENST00000443099 | ENST00000319888 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| 5CDS-5UTR | ENST00000443099 | ENST00000574538 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| 5CDS-5UTR | ENST00000562706 | ENST00000319888 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
| 5CDS-5UTR | ENST00000562706 | ENST00000574538 | TMX3 | chr18 | 66378601 | - | METTL4 | chr18 | 2567653 | - |
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FusionProtFeatures for TMX3_METTL4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMX3 | METTL4 |