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Fusion gene ID: 38766 |
FusionGeneSummary for TMPRSS2_SARS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMPRSS2_SARS | Fusion gene ID: 38766 | Hgene | Tgene | Gene symbol | TMPRSS2 | SARS | Gene ID | 7113 | 54938 |
| Gene name | transmembrane serine protease 2 | seryl-tRNA synthetase 2, mitochondrial | |
| Synonyms | PP9284|PRSS10 | SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS | |
| Cytomap | 21q22.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | serine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15393 | P49591 | |
| Ensembl transtripts involved in fusion gene | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | ENST00000234677, ENST00000369923, ENST00000468588, | |
| Fusion gene scores | * DoF score | 29 X 21 X 6=3654 | 6 X 5 X 4=120 |
| # samples | 228 | 7 | |
| ** MAII score | log2(228/3654*10)=-0.680442809575384 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMPRSS2 [Title/Abstract] AND SARS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
| Hgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-8474-01A | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000332149 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000332149 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000332149 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000398585 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| In-frame | ENST00000398585 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000398585 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| Frame-shift | ENST00000458356 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| Frame-shift | ENST00000458356 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| 5CDS-intron | ENST00000458356 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| intron-3CDS | ENST00000497881 | ENST00000234677 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| intron-3CDS | ENST00000497881 | ENST00000369923 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
| intron-intron | ENST00000497881 | ENST00000468588 | TMPRSS2 | chr21 | 42860321 | - | SARS | chr1 | 109766600 | + |
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FusionProtFeatures for TMPRSS2_SARS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMPRSS2 | SARS |