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Fusion gene ID: 38694 |
FusionGeneSummary for TMEM87B_IL1RN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM87B_IL1RN | Fusion gene ID: 38694 | Hgene | Tgene | Gene symbol | TMEM87B | IL1RN | Gene ID | 84910 | 3557 |
| Gene name | transmembrane protein 87B | interleukin 1 receptor antagonist | |
| Synonyms | - | DIRA|ICIL-1RA|IL-1RN|IL-1ra|IL-1ra3|IL1F3|IL1RA|IRAP|MVCD4 | |
| Cytomap | 2q13 | 2q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 87B | interleukin-1 receptor antagonist proteinIL1 inhibitorintracellular IL-1 receptor antagonist type IIintracellular interleukin-1 receptor antagonist (icIL-1ra)type II interleukin-1 receptor antagonist | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q96K49 | P18510 | |
| Ensembl transtripts involved in fusion gene | ENST00000283206, ENST00000463427, | ENST00000465812, ENST00000409052, ENST00000361779, ENST00000259206, ENST00000354115, ENST00000409930, | |
| Fusion gene scores | * DoF score | 4 X 7 X 9=252 | 7 X 4 X 6=168 |
| # samples | 12 | 9 | |
| ** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM87B [Title/Abstract] AND IL1RN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IL1RN | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 2139180 |
| Tgene | IL1RN | GO:0051384 | response to glucocorticoid | 10443688 |
| Tgene | IL1RN | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 2137200|2139180 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-4357-01A | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000283206 | ENST00000465812 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-3UTR | ENST00000283206 | ENST00000409052 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000361779 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000259206 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000354115 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 5CDS-intron | ENST00000283206 | ENST00000409930 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-3UTR | ENST00000463427 | ENST00000465812 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-3UTR | ENST00000463427 | ENST00000409052 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000361779 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000259206 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000354115 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
| 3UTR-intron | ENST00000463427 | ENST00000409930 | TMEM87B | chr2 | 112847295 | + | IL1RN | chr2 | 113868693 | + |
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FusionProtFeatures for TMEM87B_IL1RN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM87B | IL1RN |