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Fusion gene ID: 38657 |
FusionGeneSummary for TMEM59_SSBP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM59_SSBP3 | Fusion gene ID: 38657 | Hgene | Tgene | Gene symbol | TMEM59 | SSBP3 | Gene ID | 9528 | 23648 |
| Gene name | transmembrane protein 59 | single stranded DNA binding protein 3 | |
| Synonyms | C1orf8|DCF1|HSPC001|PRO195|UNQ169 | CSDP|SSDP|SSDP1 | |
| Cytomap | 1p32.3 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 59dendritic cell factor 1liver membrane-bound protein | single-stranded DNA-binding protein 3sequence-specific single-stranded-DNA-binding protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BXS4 | Q9BWW4 | |
| Ensembl transtripts involved in fusion gene | ENST00000371348, ENST00000371344, ENST00000234831, ENST00000371341, ENST00000470395, ENST00000371337, | ENST00000326956, ENST00000417664, ENST00000371320, ENST00000371319, ENST00000357475, | |
| Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 11 X 8 X 6=528 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/528*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM59 [Title/Abstract] AND SSBP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM59 | GO:0010955 | negative regulation of protein processing | 20427278 |
| Hgene | TMEM59 | GO:0090285 | negative regulation of protein glycosylation in Golgi | 20427278 |
| Hgene | TMEM59 | GO:1903077 | negative regulation of protein localization to plasma membrane | 20427278 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-A91K-01A | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000371348 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371348 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371348 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371348 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000371348 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371344 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000371344 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000234831 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000234831 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-5UTR | ENST00000371341 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5CDS-intron | ENST00000371341 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-5UTR | ENST00000470395 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| 5UTR-intron | ENST00000470395 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000326956 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000417664 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000371320 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-5UTR | ENST00000371337 | ENST00000371319 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
| intron-intron | ENST00000371337 | ENST00000357475 | TMEM59 | chr1 | 54502283 | - | SSBP3 | chr1 | 54722859 | - |
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FusionProtFeatures for TMEM59_SSBP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM59 | SSBP3 |