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Fusion gene ID: 38641 |
FusionGeneSummary for TMEM52B_RHNO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM52B_RHNO1 | Fusion gene ID: 38641 | Hgene | Tgene | Gene symbol | TMEM52B | RHNO1 | Gene ID | 120939 | 83695 |
| Gene name | transmembrane protein 52B | RAD9-HUS1-RAD1 interacting nuclear orphan 1 | |
| Synonyms | C12orf59 | C12orf32|HKMT1188|RHINO | |
| Cytomap | 12p13.2 | 12p13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 52B | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1Rad9, Rad1, Hus1 interacting nuclear orphanrAD9, RAD1, HUS1-interacting nuclear orphan protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q4KMG9 | Q9BSD3 | |
| Ensembl transtripts involved in fusion gene | ENST00000381923, ENST00000545924, ENST00000298530, ENST00000536952, | ENST00000461997, ENST00000464682, ENST00000489288, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TMEM52B [Title/Abstract] AND RHNO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RHNO1 | GO:0034644 | cellular response to UV | 21659603 |
| Tgene | RHNO1 | GO:0071479 | cellular response to ionizing radiation | 21659603 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1N9-01A | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000381923 | ENST00000461997 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-intron | ENST00000381923 | ENST00000464682 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-5UTR | ENST00000381923 | ENST00000489288 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| intron-5UTR | ENST00000545924 | ENST00000461997 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| intron-intron | ENST00000545924 | ENST00000464682 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| intron-5UTR | ENST00000545924 | ENST00000489288 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-5UTR | ENST00000298530 | ENST00000461997 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-intron | ENST00000298530 | ENST00000464682 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-5UTR | ENST00000298530 | ENST00000489288 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-5UTR | ENST00000536952 | ENST00000461997 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-intron | ENST00000536952 | ENST00000464682 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
| 5CDS-5UTR | ENST00000536952 | ENST00000489288 | TMEM52B | chr12 | 10339188 | + | RHNO1 | chr12 | 2994449 | + |
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FusionProtFeatures for TMEM52B_RHNO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM52B | RHNO1 |