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Fusion gene ID: 38619 |
FusionGeneSummary for TMEM39A_EPHA6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM39A_EPHA6 | Fusion gene ID: 38619 | Hgene | Tgene | Gene symbol | TMEM39A | EPHA6 | Gene ID | 55254 | 285220 |
| Gene name | transmembrane protein 39A | EPH receptor A6 | |
| Synonyms | - | EHK-2|EHK2|EK12|EPA6|HEK12|PRO57066 | |
| Cytomap | 3q13.33 | 3q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 39A | ephrin type-A receptor 6EPH homology kinase 2EPH-like kinase 12ephrin receptor EphA6 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NV64 | Q9UF33 | |
| Ensembl transtripts involved in fusion gene | ENST00000319172, ENST00000486159, | ENST00000470610, ENST00000389672, ENST00000542517, ENST00000514100, ENST00000502694, ENST00000442602, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 8 X 8 X 4=256 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM39A [Title/Abstract] AND EPHA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5505-01A | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000319172 | ENST00000470610 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| Frame-shift | ENST00000319172 | ENST00000389672 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| Frame-shift | ENST00000319172 | ENST00000542517 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| 5CDS-intron | ENST00000319172 | ENST00000514100 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| 5CDS-intron | ENST00000319172 | ENST00000502694 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| 5CDS-intron | ENST00000319172 | ENST00000442602 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| intron-3CDS | ENST00000486159 | ENST00000470610 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| intron-3CDS | ENST00000486159 | ENST00000389672 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| intron-3CDS | ENST00000486159 | ENST00000542517 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| intron-intron | ENST00000486159 | ENST00000514100 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| intron-intron | ENST00000486159 | ENST00000502694 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
| intron-intron | ENST00000486159 | ENST00000442602 | TMEM39A | chr3 | 119171294 | - | EPHA6 | chr3 | 96706174 | + |
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FusionProtFeatures for TMEM39A_EPHA6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM39A | EPHA6 |