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Fusion gene ID: 38612 |
FusionGeneSummary for TMEM35_SLC25A43 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM35_SLC25A43 | Fusion gene ID: 38612 | Hgene | Tgene | Gene symbol | TMEM35 | SLC25A43 | Gene ID | 59353 | 203427 |
| Gene name | transmembrane protein 35A | solute carrier family 25 member 43 | |
| Synonyms | TMEM35 | - | |
| Cytomap | Xq22.1 | Xq24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 35Atransmembrane protein 35 | solute carrier family 25 member 43 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8WUT9 | ||
| Ensembl transtripts involved in fusion gene | ENST00000372930, ENST00000478351, | ENST00000217909, ENST00000336249, ENST00000488158, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 5 X 2=30 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TMEM35 [Title/Abstract] AND SLC25A43 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-3B-A9HV-01A | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000372930 | ENST00000217909 | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
| Frame-shift | ENST00000372930 | ENST00000336249 | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
| 5CDS-3UTR | ENST00000372930 | ENST00000488158 | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
| intron-3CDS | ENST00000478351 | ENST00000217909 | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
| intron-3CDS | ENST00000478351 | ENST00000336249 | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
| intron-3UTR | ENST00000478351 | ENST00000488158 | TMEM35 | chrX | 100334111 | + | SLC25A43 | chrX | 118585972 | + |
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FusionProtFeatures for TMEM35_SLC25A43 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM35 | SLC25A43 |