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Fusion gene ID: 38609 |
FusionGeneSummary for TMEM33_PILRB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM33_PILRB | Fusion gene ID: 38609 | Hgene | Tgene | Gene symbol | TMEM33 | PILRB | Gene ID | 55161 | 29990 |
| Gene name | transmembrane protein 33 | paired immunoglobin-like type 2 receptor beta | |
| Synonyms | 1600019D15Rik|SHINC-3|SHINC3 | FDFACT1|FDFACT2 | |
| Cytomap | 4p13 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 33 | paired immunoglobulin-like type 2 receptor betaactivating receptor PILR-betaactivating receptor PILRbetacell surface receptor FDFACTcell surface receptor FDFACT1cell surface receptor FDFACT2paired immunoglobin-like receptor betapaired immunoglobuli | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P57088 | Q9UKJ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000504986, ENST00000513702, ENST00000325094, | ENST00000610247, ENST00000452089, ENST00000448382, ENST00000444073, ENST00000609309, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TMEM33 [Title/Abstract] AND PILRB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM33 | GO:0034976 | response to endoplasmic reticulum stress | 26268696 |
| Hgene | TMEM33 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization | 25612671 |
| Hgene | TMEM33 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response | 26268696 |
| Hgene | TMEM33 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response | 26268696 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF733642 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000504986 | ENST00000610247 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| In-frame | ENST00000504986 | ENST00000452089 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000504986 | ENST00000448382 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000504986 | ENST00000444073 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000504986 | ENST00000609309 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| In-frame | ENST00000513702 | ENST00000610247 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| In-frame | ENST00000513702 | ENST00000452089 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000513702 | ENST00000448382 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000513702 | ENST00000444073 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000513702 | ENST00000609309 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| In-frame | ENST00000325094 | ENST00000610247 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| In-frame | ENST00000325094 | ENST00000452089 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000325094 | ENST00000448382 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000325094 | ENST00000444073 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
| 5CDS-intron | ENST00000325094 | ENST00000609309 | TMEM33 | chr4 | 41941234 | - | PILRB | chr7 | 99956449 | - |
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FusionProtFeatures for TMEM33_PILRB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM33 | PILRB |