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Fusion gene ID: 38592 |
FusionGeneSummary for TMEM259_MBOAT7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM259_MBOAT7 | Fusion gene ID: 38592 | Hgene | Tgene | Gene symbol | TMEM259 | MBOAT7 | Gene ID | 91304 | 79143 |
| Gene name | transmembrane protein 259 | membrane bound O-acyltransferase domain containing 7 | |
| Synonyms | ASBABP1|C19orf6|MBRL|MEMBRALIN|R32184_3 | BB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7 | |
| Cytomap | 19p13.3 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | membralinaspecific BCL2 ARE-binding protein 1 | lysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol ac | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q4ZIN3 | Q96N66 | |
| Ensembl transtripts involved in fusion gene | ENST00000356663, ENST00000333175, | ENST00000431666, ENST00000338624, ENST00000245615, ENST00000391754, ENST00000474910, | |
| Fusion gene scores | * DoF score | 9 X 7 X 4=252 | 5 X 5 X 3=75 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM259 [Title/Abstract] AND MBOAT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF877350 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000356663 | ENST00000431666 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-3CDS | ENST00000356663 | ENST00000338624 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-3CDS | ENST00000356663 | ENST00000245615 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-intron | ENST00000356663 | ENST00000391754 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-intron | ENST00000356663 | ENST00000474910 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-3CDS | ENST00000333175 | ENST00000431666 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-3CDS | ENST00000333175 | ENST00000338624 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-3CDS | ENST00000333175 | ENST00000245615 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-intron | ENST00000333175 | ENST00000391754 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
| intron-intron | ENST00000333175 | ENST00000474910 | TMEM259 | chr19 | 1012159 | + | MBOAT7 | chr19 | 54678003 | - |
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FusionProtFeatures for TMEM259_MBOAT7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM259 | MBOAT7 |