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Fusion gene ID: 3858 |
FusionGeneSummary for BAZ1B_FNIP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAZ1B_FNIP2 | Fusion gene ID: 3858 | Hgene | Tgene | Gene symbol | BAZ1B | FNIP2 | Gene ID | 9031 | 57600 |
| Gene name | bromodomain adjacent to zinc finger domain 1B | folliculin interacting protein 2 | |
| Synonyms | WBSCR10|WBSCR9|WSTF | FNIPL|MAPO1 | |
| Cytomap | 7q11.23 | 4q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase BAZ1BhWALp2transcription factor WSTFwilliams syndrome transcription factorwilliams-Beuren syndrome chromosomal region 10 proteinwilliams-Beuren syndrome chromosomal region 9 protein | folliculin-interacting protein 2FNIP1-like proteinO6-methylguanine-induced apoptosis 1 protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9UIG0 | Q9P278 | |
| Ensembl transtripts involved in fusion gene | ENST00000339594, ENST00000404251, | ENST00000264433, ENST00000379346, ENST00000505445, | |
| Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 4 X 4 X 2=32 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/432*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BAZ1B [Title/Abstract] AND FNIP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAZ1B | GO:0006974 | cellular response to DNA damage stimulus | 19092802 |
| Hgene | BAZ1B | GO:0016572 | histone phosphorylation | 19092802 |
| Tgene | FNIP2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21209915 |
| Tgene | FNIP2 | GO:0001932 | regulation of protein phosphorylation | 18663353 |
| Tgene | FNIP2 | GO:0006468 | protein phosphorylation | 18663353 |
| Tgene | FNIP2 | GO:0031334 | positive regulation of protein complex assembly | 25126726 |
| Tgene | FNIP2 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19914239 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE771024 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000339594 | ENST00000264433 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
| intron-intron | ENST00000339594 | ENST00000379346 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
| intron-intron | ENST00000339594 | ENST00000505445 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
| intron-intron | ENST00000404251 | ENST00000264433 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
| intron-intron | ENST00000404251 | ENST00000379346 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
| intron-intron | ENST00000404251 | ENST00000505445 | BAZ1B | chr7 | 72891663 | + | FNIP2 | chr4 | 159707199 | + |
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FusionProtFeatures for BAZ1B_FNIP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAZ1B | FNIP2 |