|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38577 |
FusionGeneSummary for TMEM246_TMEM246 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM246_TMEM246 | Fusion gene ID: 38577 | Hgene | Tgene | Gene symbol | TMEM246 | TMEM246 | Gene ID | 84302 | 84302 |
| Gene name | transmembrane protein 246 | transmembrane protein 246 | |
| Synonyms | C9orf125 | C9orf125 | |
| Cytomap | 9q31.1 | 9q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 246transmembrane protein C9orf125 | transmembrane protein 246transmembrane protein C9orf125 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BRR3 | Q9BRR3 | |
| Ensembl transtripts involved in fusion gene | ENST00000374847, ENST00000374848, ENST00000374851, ENST00000482920, | ENST00000374847, ENST00000374848, ENST00000374851, ENST00000482920, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TMEM246 [Title/Abstract] AND TMEM246 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF110047 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000374847 | ENST00000374847 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374847 | ENST00000374848 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374847 | ENST00000374851 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-intron | ENST00000374847 | ENST00000482920 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374848 | ENST00000374847 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374848 | ENST00000374848 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374848 | ENST00000374851 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-intron | ENST00000374848 | ENST00000482920 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374851 | ENST00000374847 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374851 | ENST00000374848 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000374851 | ENST00000374851 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-intron | ENST00000374851 | ENST00000482920 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000482920 | ENST00000374847 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000482920 | ENST00000374848 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-3UTR | ENST00000482920 | ENST00000374851 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
| intron-intron | ENST00000482920 | ENST00000482920 | TMEM246 | chr9 | 104238187 | + | TMEM246 | chr9 | 104238140 | - |
Top |
FusionProtFeatures for TMEM246_TMEM246 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM246 | TMEM246 |