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Fusion gene ID: 38562

FusionGeneSummary for TMEM241_SNX29

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM241_SNX29
	Fusion gene ID: 38562
		Hgene	Tgene
	Gene symbol	TMEM241	SNX29
	Gene ID	85019	92017
	Gene name	transmembrane protein 241	sorting nexin 29
	Synonyms	C18orf45\|hVVT	A-388D4.1\|RUNDC2A
	Cytomap	18q11.2	16p13.13-p13.12
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45	sorting nexin-29RUN domain containing 2ARUN domain-containing protein 2A
	Modification date	20180519	20180519
	UniProtAcc	Q24JQ0	Q8TEQ0
	Ensembl transtripts involved in fusion gene	ENST00000450466, ENST00000383233, ENST00000542162, ENST00000399707, ENST00000475185,	ENST00000566228, ENST00000323433, ENST00000306030, ENST00000568359,
Fusion gene scores	* DoF score	5 X 5 X 6=150	9 X 8 X 6=432
	# samples	7	9
	** MAII score	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM241 [Title/Abstract] AND SNX29 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-MP-A5C7-01A	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000450466	ENST00000566228	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-3CDS	ENST00000450466	ENST00000323433	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-3CDS	ENST00000450466	ENST00000306030	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-intron	ENST00000450466	ENST00000568359	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000383233	ENST00000566228	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000383233	ENST00000323433	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000383233	ENST00000306030	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
5CDS-intron	ENST00000383233	ENST00000568359	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000542162	ENST00000566228	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000542162	ENST00000323433	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000542162	ENST00000306030	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
5CDS-intron	ENST00000542162	ENST00000568359	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000399707	ENST00000566228	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000399707	ENST00000323433	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
In-frame	ENST00000399707	ENST00000306030	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
5CDS-intron	ENST00000399707	ENST00000568359	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-3CDS	ENST00000475185	ENST00000566228	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-3CDS	ENST00000475185	ENST00000323433	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-3CDS	ENST00000475185	ENST00000306030	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+
intron-intron	ENST00000475185	ENST00000568359	TMEM241	chr18	20979530	-	SNX29	chr16	12492303	+

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FusionProtFeatures for TMEM241_SNX29

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMEM241 Q24JQ0	SNX29 Q8TEQ0

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Fusion gene ID: 38562

FusionGeneSummary for TMEM241_SNX29

FusionProtFeatures for TMEM241_SNX29