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Fusion gene ID: 38551 |
FusionGeneSummary for TMEM223_SLC22A8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM223_SLC22A8 | Fusion gene ID: 38551 | Hgene | Tgene | Gene symbol | TMEM223 | SLC22A8 | Gene ID | 79064 | 9376 |
| Gene name | transmembrane protein 223 | solute carrier family 22 member 8 | |
| Synonyms | - | OAT3 | |
| Cytomap | 11q12.3 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 223 | solute carrier family 22 member 8hOAT3organic anion transporter 3solute carrier family 22 (organic anion transporter), member 8 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | A0PJW6 | Q8TCC7 | |
| Ensembl transtripts involved in fusion gene | ENST00000527073, ENST00000525631, ENST00000307366, | ENST00000336232, ENST00000545207, ENST00000535878, ENST00000311438, ENST00000430500, ENST00000542795, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 4 X 5 X 3=60 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM223 [Title/Abstract] AND SLC22A8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-BW-A5NO-01A | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000527073 | ENST00000336232 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5UTR-3CDS | ENST00000527073 | ENST00000545207 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5UTR-3CDS | ENST00000527073 | ENST00000535878 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5UTR-3CDS | ENST00000527073 | ENST00000311438 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5UTR-3CDS | ENST00000527073 | ENST00000430500 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5UTR-intron | ENST00000527073 | ENST00000542795 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000525631 | ENST00000336232 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000525631 | ENST00000545207 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000525631 | ENST00000535878 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000525631 | ENST00000311438 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000525631 | ENST00000430500 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5CDS-intron | ENST00000525631 | ENST00000542795 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000307366 | ENST00000336232 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000307366 | ENST00000545207 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000307366 | ENST00000535878 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000307366 | ENST00000311438 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| Frame-shift | ENST00000307366 | ENST00000430500 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
| 5CDS-intron | ENST00000307366 | ENST00000542795 | TMEM223 | chr11 | 62559151 | - | SLC22A8 | chr11 | 62761350 | - |
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FusionProtFeatures for TMEM223_SLC22A8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM223 | SLC22A8 |