	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 38546

FusionGeneSummary for TMEM219_CPB1

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM219_CPB1
	Fusion gene ID: 38546
		Hgene	Tgene
	Gene symbol	TMEM219	CPB1
	Gene ID	124446	1360
	Gene name	transmembrane protein 219	carboxypeptidase B1
	Synonyms	IGFBP-3R	CPB\|PASP\|PCPB
	Cytomap	16p11.2	3q24
	Type of gene	protein-coding	protein-coding
	Description	insulin-like growth factor-binding protein 3 receptortesticular tissue protein Li 203	carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B
	Modification date	20180519	20180523
	UniProtAcc	Q86XT9	P15086
	Ensembl transtripts involved in fusion gene	ENST00000414689, ENST00000279396, ENST00000561899, ENST00000566848,	ENST00000491148, ENST00000282957, ENST00000498639,
Fusion gene scores	* DoF score	1 X 1 X 1=1	21 X 24 X 3=1512
	# samples	1	19
	** MAII score	log2(1/1*10)=3.32192809488736	log2(19/1512*10)=-2.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM219 [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-A8-A06Z-01A	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000414689	ENST00000491148	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-3CDS	ENST00000414689	ENST00000282957	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-intron	ENST00000414689	ENST00000498639	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-3CDS	ENST00000279396	ENST00000491148	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-3CDS	ENST00000279396	ENST00000282957	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-intron	ENST00000279396	ENST00000498639	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
3UTR-3CDS	ENST00000561899	ENST00000491148	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
3UTR-3CDS	ENST00000561899	ENST00000282957	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
3UTR-intron	ENST00000561899	ENST00000498639	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-3CDS	ENST00000566848	ENST00000491148	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-3CDS	ENST00000566848	ENST00000282957	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+
intron-intron	ENST00000566848	ENST00000498639	TMEM219	chr16	29983099	+	CPB1	chr3	148558489	+

Top

FusionProtFeatures for TMEM219_CPB1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMEM219 Q86XT9	CPB1 P15086

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 38546

FusionGeneSummary for TMEM219_CPB1

FusionProtFeatures for TMEM219_CPB1