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Fusion gene ID: 38499 |
FusionGeneSummary for TMEM179B_TCEAL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM179B_TCEAL3 | Fusion gene ID: 38499 | Hgene | Tgene | Gene symbol | TMEM179B | TCEAL3 | Gene ID | 374395 | 85012 |
| Gene name | transmembrane protein 179B | transcription elongation factor A like 3 | |
| Synonyms | - | WEX8 | |
| Cytomap | 11q12.3 | Xq22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 179B | transcription elongation factor A protein-like 3TCEA-like protein 3transcription elongation factor A (SII)-like 3transcription elongation factor S-II protein-like 3 | |
| Modification date | 20180524 | 20180523 | |
| UniProtAcc | Q7Z7N9 | Q969E4 | |
| Ensembl transtripts involved in fusion gene | ENST00000533861, ENST00000333449, | ENST00000372628, ENST00000243286, ENST00000372627, ENST00000477014, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TMEM179B [Title/Abstract] AND TCEAL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB053892 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000533861 | ENST00000372628 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-3CDS | ENST00000533861 | ENST00000243286 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-3CDS | ENST00000533861 | ENST00000372627 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-intron | ENST00000533861 | ENST00000477014 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-3CDS | ENST00000333449 | ENST00000372628 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-3CDS | ENST00000333449 | ENST00000243286 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-3CDS | ENST00000333449 | ENST00000372627 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
| 3UTR-intron | ENST00000333449 | ENST00000477014 | TMEM179B | chr11 | 62557651 | - | TCEAL3 | chrX | 102864548 | + |
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FusionProtFeatures for TMEM179B_TCEAL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM179B | TCEAL3 |