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Fusion gene ID: 38498 |
FusionGeneSummary for TMEM179B_SLC22A10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM179B_SLC22A10 | Fusion gene ID: 38498 | Hgene | Tgene | Gene symbol | TMEM179B | SLC22A10 | Gene ID | 374395 | 387775 |
| Gene name | transmembrane protein 179B | solute carrier family 22 member 10 | |
| Synonyms | - | OAT5|hOAT5 | |
| Cytomap | 11q12.3 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 179B | solute carrier family 22 member 10organic anion transporter 5solute carrier family 22 (organic anion/cation transporter), member 10 | |
| Modification date | 20180524 | 20180522 | |
| UniProtAcc | Q7Z7N9 | Q63ZE4 | |
| Ensembl transtripts involved in fusion gene | ENST00000533861, ENST00000333449, | ENST00000525620, ENST00000535888, ENST00000544661, ENST00000332793, ENST00000526800, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 4 X 4 X 4=64 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM179B [Title/Abstract] AND SLC22A10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-J4-A6M7-01A | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000533861 | ENST00000525620 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-5UTR | ENST00000533861 | ENST00000535888 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-5UTR | ENST00000533861 | ENST00000544661 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-5UTR | ENST00000533861 | ENST00000332793 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-intron | ENST00000533861 | ENST00000526800 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-3UTR | ENST00000333449 | ENST00000525620 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-5UTR | ENST00000333449 | ENST00000535888 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-5UTR | ENST00000333449 | ENST00000544661 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-5UTR | ENST00000333449 | ENST00000332793 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
| 5CDS-intron | ENST00000333449 | ENST00000526800 | TMEM179B | chr11 | 62556898 | + | SLC22A10 | chr11 | 63064775 | + |
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FusionProtFeatures for TMEM179B_SLC22A10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM179B | SLC22A10 |