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Fusion gene ID: 38467

FusionGeneSummary for TMEM167A_ABLIM3

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM167A_ABLIM3
	Fusion gene ID: 38467
		Hgene	Tgene
	Gene symbol	TMEM167A	ABLIM3
	Gene ID	153339	22885
	Gene name	transmembrane protein 167A	actin binding LIM protein family member 3
	Synonyms	TMEM167	HMFN1661
	Cytomap	5q14.2	5q32
	Type of gene	protein-coding	protein-coding
	Description	protein kish-Atransmembrane protein 167	actin-binding LIM protein 3abLIM-3
	Modification date	20180523	20180523
	UniProtAcc	Q8TBQ9	O94929
	Ensembl transtripts involved in fusion gene	ENST00000502346, ENST00000511450,	ENST00000326685, ENST00000356541, ENST00000309868, ENST00000506113, ENST00000504238, ENST00000508983, ENST00000517451, ENST00000519549,
Fusion gene scores	* DoF score	4 X 3 X 2=24	1 X 1 X 1=1
	# samples	2	1
	** MAII score	log2(2/24*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: TMEM167A [Title/Abstract] AND ABLIM3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-EB-A5KH-06A	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
TCGA	LD	SKCM	TCGA-EB-A5KH-06A	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000502346	ENST00000326685	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
Frame-shift	ENST00000502346	ENST00000356541	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
Frame-shift	ENST00000502346	ENST00000309868	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
Frame-shift	ENST00000502346	ENST00000506113	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
Frame-shift	ENST00000502346	ENST00000504238	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
Frame-shift	ENST00000502346	ENST00000508983	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5CDS-intron	ENST00000502346	ENST00000517451	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5CDS-intron	ENST00000502346	ENST00000519549	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000326685	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000356541	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000309868	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000506113	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000504238	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000508983	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-intron	ENST00000511450	ENST00000517451	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
5UTR-intron	ENST00000511450	ENST00000519549	TMEM167A	chr5	82357696	-	ABLIM3	chr5	148596522	+
In-frame	ENST00000502346	ENST00000326685	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
In-frame	ENST00000502346	ENST00000356541	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
In-frame	ENST00000502346	ENST00000309868	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
In-frame	ENST00000502346	ENST00000506113	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
In-frame	ENST00000502346	ENST00000504238	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
In-frame	ENST00000502346	ENST00000508983	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5CDS-intron	ENST00000502346	ENST00000517451	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5CDS-intron	ENST00000502346	ENST00000519549	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000326685	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000356541	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000309868	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000506113	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000504238	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-3CDS	ENST00000511450	ENST00000508983	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-intron	ENST00000511450	ENST00000517451	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+
5UTR-intron	ENST00000511450	ENST00000519549	TMEM167A	chr5	82373140	-	ABLIM3	chr5	148596522	+

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FusionProtFeatures for TMEM167A_ABLIM3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMEM167A Q8TBQ9	ABLIM3 O94929

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Fusion gene ID: 38467

FusionGeneSummary for TMEM167A_ABLIM3

FusionProtFeatures for TMEM167A_ABLIM3