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Fusion gene ID: 38432 |
FusionGeneSummary for TMEM138_CBX5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM138_CBX5 | Fusion gene ID: 38432 | Hgene | Tgene | Gene symbol | TMEM138 | CBX5 | Gene ID | 51524 | 23468 |
| Gene name | transmembrane protein 138 | chromobox 5 | |
| Synonyms | HSPC196 | HEL25|HP1|HP1A | |
| Cytomap | 11q12.2 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 138 | chromobox protein homolog 5HP1 alpha homologHP1-ALPHAHP1Hs alphaantigen p25chromobox homolog 5 (HP1 alpha homolog, Drosophila)epididymis luminal protein 25heterochromatin protein 1 homolog alphaheterochromatin protein 1-alpha | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NPI0 | P45973 | |
| Ensembl transtripts involved in fusion gene | ENST00000278826, ENST00000542946, ENST00000540194, ENST00000381787, | ENST00000209875, ENST00000439541, ENST00000550411, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 3=75 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/4*10)=2.90689059560852 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM138 [Title/Abstract] AND CBX5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CBX5 | GO:0045892 | negative regulation of transcription, DNA-templated | 9636147 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG953951 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000278826 | ENST00000209875 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| 5CDS-intron | ENST00000278826 | ENST00000439541 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| 5CDS-intron | ENST00000278826 | ENST00000550411 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| intron-3UTR | ENST00000542946 | ENST00000209875 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| intron-intron | ENST00000542946 | ENST00000439541 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| intron-intron | ENST00000542946 | ENST00000550411 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| intron-3UTR | ENST00000540194 | ENST00000209875 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| intron-intron | ENST00000540194 | ENST00000439541 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| intron-intron | ENST00000540194 | ENST00000550411 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| 5CDS-3UTR | ENST00000381787 | ENST00000209875 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| 5CDS-intron | ENST00000381787 | ENST00000439541 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
| 5CDS-intron | ENST00000381787 | ENST00000550411 | TMEM138 | chr11 | 61136159 | + | CBX5 | chr12 | 54633912 | + |
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FusionProtFeatures for TMEM138_CBX5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM138 | CBX5 |