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Fusion gene ID: 38411 |
FusionGeneSummary for TMEM132D_GALNT9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM132D_GALNT9 | Fusion gene ID: 38411 | Hgene | Tgene | Gene symbol | TMEM132D | GALNT9 | Gene ID | 121256 | 50614 |
| Gene name | transmembrane protein 132D | polypeptide N-acetylgalactosaminyltransferase 9 | |
| Synonyms | MOLT|PPP1R153 | GALNAC-T9|GALNACT9 | |
| Cytomap | 12q24.33 | 12q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 132Dmature OL transmembrane proteinmature oligodendrocytes transmembrane proteinprotein phosphatase 1, regulatory subunit 153 | polypeptide N-acetylgalactosaminyltransferase 9GalNAc transferase 9UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 9UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)polypeptide GalNAc transferase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q14C87 | Q9HCQ5 | |
| Ensembl transtripts involved in fusion gene | ENST00000422113, ENST00000389441, | ENST00000535228, ENST00000328957, ENST00000397325, ENST00000541995, ENST00000535208, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 3 X 4=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM132D [Title/Abstract] AND GALNT9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM132D | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DU-8167-01A | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000422113 | ENST00000535228 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| 5CDS-5UTR | ENST00000422113 | ENST00000328957 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| 5CDS-intron | ENST00000422113 | ENST00000397325 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| 5CDS-intron | ENST00000422113 | ENST00000541995 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| 5CDS-intron | ENST00000422113 | ENST00000535208 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| intron-5UTR | ENST00000389441 | ENST00000535228 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| intron-5UTR | ENST00000389441 | ENST00000328957 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| intron-intron | ENST00000389441 | ENST00000397325 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| intron-intron | ENST00000389441 | ENST00000541995 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
| intron-intron | ENST00000389441 | ENST00000535208 | TMEM132D | chr12 | 130015604 | - | GALNT9 | chr12 | 132824580 | - |
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FusionProtFeatures for TMEM132D_GALNT9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM132D | GALNT9 |