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Fusion gene ID: 38389 |
FusionGeneSummary for TMEM123_CENPP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM123_CENPP | Fusion gene ID: 38389 | Hgene | Tgene | Gene symbol | TMEM123 | CENPP | Gene ID | 114908 | 401541 |
| Gene name | transmembrane protein 123 | centromere protein P | |
| Synonyms | KCT3|PORIMIN|PORMIN | CENP-P | |
| Cytomap | 11q22.2 | 9q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | poriminKCT-3keratinocytes associated transmembrane protein 3pro-oncosis receptor inducing membrane injuryserine/threonine-rich receptor | centromere protein P | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8N131 | Q6IPU0 | |
| Ensembl transtripts involved in fusion gene | ENST00000361236, ENST00000398136, ENST00000532161, ENST00000525577, | ENST00000375587, ENST00000375579, ENST00000375576, | |
| Fusion gene scores | * DoF score | 7 X 3 X 8=168 | 7 X 6 X 6=252 |
| # samples | 9 | 11 | |
| ** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/252*10)=-1.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM123 [Title/Abstract] AND CENPP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM123 | GO:0070267 | oncosis | 9600958|11481458 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-E7-A7DV-01A | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000361236 | ENST00000375587 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| intron-3CDS | ENST00000361236 | ENST00000375579 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| intron-3CDS | ENST00000361236 | ENST00000375576 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| Frame-shift | ENST00000398136 | ENST00000375587 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| Frame-shift | ENST00000398136 | ENST00000375579 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| In-frame | ENST00000398136 | ENST00000375576 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| 5UTR-3CDS | ENST00000532161 | ENST00000375587 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| 5UTR-3CDS | ENST00000532161 | ENST00000375579 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| 5UTR-3CDS | ENST00000532161 | ENST00000375576 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| 5UTR-3CDS | ENST00000525577 | ENST00000375587 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| 5UTR-3CDS | ENST00000525577 | ENST00000375579 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
| 5UTR-3CDS | ENST00000525577 | ENST00000375576 | TMEM123 | chr11 | 102319543 | - | CENPP | chr9 | 95373596 | + |
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FusionProtFeatures for TMEM123_CENPP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM123 | CENPP |